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dr. frankenstein

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dr. frankenstein last won the day on October 18 2018

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  1. dr. frankenstein

    Normal Testosterone levels by age

    . ...maybe you were around 200 ......... .
  2. dr. frankenstein

    Muscle Memory Revisited

    . Journal of Experimental Biology 2016 219: 235-242. Muscle memory and a new cellular model for muscle atrophy and hypertrophy http://jeb.biologists.org/content/219/2/235 "previously untrained fibres recruit myonuclei from activated satellite cells before hypertrophic growth. Even if subsequently subjected to grave atrophy, the higher number of myonuclei is retained, and the myonuclei seem to be protected against the elevated apoptotic activity observed in atrophying muscle tissue. Fibres that have acquired a higher number of myonuclei grow faster when subjected to overload exercise, thus the nuclei represent a functionally important ‘memory’ of previous strength". but the point is, there is no donation of myonuclei from satellite cells to adult muscle cells. .
  3. dr. frankenstein

    Normal Testosterone levels by age

    . . i am on 1.100 ng/dl at 55 years old (no TRT) muscle mass normal, libido sub-standard. more testorene does not mean necessarilly a better perfomance. "some conditions apply" .......... . .
  4. dr. frankenstein

    Normal Testosterone levels by age

    . 500-600 ng/dl American Urological Association J Urol. 2018 Aug;200(2):423-432. https://www.jurology.com/article/S0022-5347(18)42817-0 "The Panel recommends that clinicians use the minimal dosing necessary to drive testosterone levels to the normal physiologic range of 450-600 ng/dL" .
  5. dr. frankenstein

    serotonin makes you stronger ?

    . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723165/ "The tryptophan-serotonin theory has been expanded from data obtained in animal studies by indication that 5-HT release and reuptake can affect central fatigue (Bequet et al. 2002). Moreover, some authors introduced the concept of the ratio of 5-HT to DA, and other neurotransmitters as more closely related variables with central fatigue" related from stendec Int J Sports Med. 1988 Oct;9(5):301-5. Effect of L-tryptophan supplementation on exercise performance. Segura R1, Ventura JL. The performance of strenuous physical exercise is associated with discomfort and pain, the tolerance for that being modulated by the activity of the endogenous opioid systems. As 5-hydroxy-tryptamine (5-HT) affects nociception through its effects on the enkephalin-endorphin system, we have analyzed the effects of a moderate supplementation with L-tryptophan, the immediate precursor of 5-HT, on endurance and sensation of effort. Twelve healthy sportsmen were subjected to a work load corresponding to 80% of their maximal oxygen uptake on two separate trials, after receiving a placebo and after receiving the same amount of L-tryptophan. The subjects ran on a treadmill until exhaustion. Total exercise time, perceived exertion rate, maximum heart rate, peak oxygen consumption, pulse recovery rate, and excess post-exercise oxygen consumption were determined during the two trials. The total exercise time was 49.4% greater after receiving L-tryptophan than after receiving the placebo. A lower rate of perceived exertion was exhibited by the group while on tryptophan although the differences from the control group were not statistically significant. No differences were observed in the other parameters between the two trials. The longer exercise time als well at the total work load performed could be due to an increased pain tolerance as a result of L-tryptophan ingestion. Int J Neurosci. 2010 May;120(5):319-27. doi: 10.3109/00207450903389404. L-tryptophan supplementation can decrease fatigue perception during an aerobic exercise with supramaximal intercalated anaerobic bouts in young healthy men. Javierre C1, Segura R, Ventura JL, Suárez A, Rosés JM. Physical exercise is often terminated not due to muscle fatigue but because of inadequate neural drive in the serotonergic system. Modifications in activity levels of the serotonergic system, induced by variations in the availability of L-tryptophan (a serotonin precursor) may alter neural drive. We examined the effect of L-tryptophan supplementation on physical performance by combining aerobic work with brief periods of supramaximal intensity that closely mimics the activity typical of team sports. Twenty healthy young sportsmen (mean age 21.2 +/- 0.7 years) performed a submaximal exercise on a cycle ergometer, with a workload corresponding to 50% of their respective VO(2) max for 10 min, followed by a maximal intensity exercise for 30 s. This sequence was repeated three times and, after the fourth series, each participant continued to exercise at the highest speed that he could sustain for 20 min. This protocol was performed twice: once with and finally without supplementation of L-tryptophan, in random order and double-blind. Peak power output, average anaerobic power output, and power output during the last 20 min of the trial were higher on the trials performed with L-tryptophan supplementation than on those performed with placebo. The distance covered during the last 20 min of the trial was 11,959 +/- 1,753 m on placebo and 12,526 +/- 1,617 m on L-tryptophan (p < .05). In conclusion, in some types of exercises, modification of the serotonergic system may improve the physical performance. .
  6. dr. frankenstein

    Hypertrophy = more ARs ?

    . i mean, more ARs -> more hypertrophy ? ...but, androgens (supaphysyological) upregulate ARs, on everybody ?... Muscle Androgen Receptor Content but Not Systemic Hormones Is Associated With Resistance Training-Induced Skeletal Muscle Hypertrophy https://www.frontiersin.org/articles/10.3389/fphys.2018.01373/full ...This study, in conjunction with others (Bamman et al., 2007; Petrella et al., 2008; Davidsen et al., 2011; Eynon et al., 2013), provides evidence that the relative increase in skeletal muscle mass following RET is underpinned by local intramuscular factors and not systemic hormonal concentrations... .
  7. dr. frankenstein

    Hypertrophy, no role for satellite cells (on adults)

    . then, what are satellite cells for ?? on adult cells... Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30304-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590916303046%3Fshowall%3Dtrue "shows MPC-mediated regulation of the muscle extracellular matrix during remodeling, and the mechanism of this interaction with fibrogenic cells" Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy https://www.frontiersin.org/articles/10.3389/fphys.2018.00635/full "satellite cell proliferation with loading, particularly in early phases but potentially throughout training, is likely for the purposes of supporting muscle repair and extracellular matrix remodeling" Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation https://www.physiology.org/doi/full/10.1152/physiol.00019.2017?url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org&amp;rfr_dat=cr_pub%3Dpubmed "an exosome-mediated mechanism by which satellite cells remodel the ECM" .
  8. dr. frankenstein

    Proven Non-Hormonal Exercise Performance Boosting Agents

    what a big letters !!! what a dominant !!! .
  9. dr. frankenstein

    Sublimation, culture, and creativity.

    https://dreams.ucsc.edu/Library/domhoff_2000d.html "On the other hand, and contrary to the claim that the method is free of any suggestive influence by the psychoanalyst, there is experimental evidence that subtle suggestions from an experimenter-therapist can falsely convince many people on the basis of dream interpretations that they were once lost or abandoned as young children (Mazzoni & Loftus, 1998; Mazzoni, Loftus, Seitz, & Lynn, 1999). These and many other findings on the power of suggestion in a therapeutic context (Ofshe & Watters, 1994) take on greater importance when Freud's (1900) several mentions of arguments with patients concerning the wishful and infantile basis of their dreams are added to the picture. What Freud saw as overcoming "resistance" can be understood from the vantage point of social psychology as a process of persuasion and conversion within the context of great respect for an authority figure who is seen as offering relief from suffering. As can be seen from this brief overview of the relevant scientific literature on dreams, there is no reason to believe any of Freud's specific claims about dreams and their purposes. It is as likely that social influence processes led to Freud's "discoveries" as it is that free association uncovers the latent content of dreams. Moreover, the all-important wish theory is refuted by the dreams of post-traumatic stress disorder and the blandness of young children's dreams. The idea of dreams as guardians of sleep is contradicted by both the regularity of dreaming and the absence of dreaming in children and brain-lesioned patients. The lack of evidence for the processes called the dream-work suggests that they are at best forms of figurative thought familiar to us through jokes and slang (Hall, 1953a). Since there are many dreams without day residue, it cannot be the case that all dreams contain a reference to events from the previous day or two. These stark conclusions leave us with nothing that is explicitly "Freudian" in the search for a general psychological theory of dreams except that at least some dreams have psychological meaning" "However, none of these ideas implies that dreams have any "purpose" or adaptive function, and least of all the functions proposed for them by Freud and Jung (Antrobus, 1993; Foulkes, 1993). Dreams are too rarely remembered or related to daily events, and too infrequently contain even the hint of solutions to problems, to have any use to the waking mind in any evolutionary sense, and there is no evidence that dreaming has any adaptive purpose during sleep. Dreaming may well be the accidental by-product of two important adaptations, thinking and sleeping (Foulkes, 1985; Foulkes, 1993; Foulkes, 1999)"
  10. dr. frankenstein

    Sublimation, culture, and creativity.

    . Psychoanalysis? Is That Still Around? .
  11. . ...well, I did not know where to post this remembering endless discussions on the role of satellite cells in hypertrophy at mindandmuscle.net Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation https://www.physiology.org/doi/abs/10.1152/physiol.00019.2017?fbclid=IwAR2G09SBA2IneSSynQzuuFQ3ZXHJDb0h4ufoHEFEodm5cpLo3Ig4g7bk_18&amp;journalCode=physiologyonline "INCREASED baseline SATELLITE CELL density in adult mice DOES NOT result in LARGER muscle fibers, indicating that satellite cells themselves DO NOT DRIVE ADULT MUSCLE FIBER GROWTH" then, what drives hypertrophy ?? increase in cytoplasmic volume and nucleus growth ....not more myonuclei Turn Up the Volume: Uncovering Nucleus Size Control Mechanisms https://www.physiology.org/doi/abs/10.1152/physiol.00019.2017?fbclid=IwAR2G09SBA2IneSSynQzuuFQ3ZXHJDb0h4ufoHEFEodm5cpLo3Ig4g7bk_18&amp;journalCode=physiologyonline "nucleus growth is regulated by the volume of cytoplasm in the immediate vicinity of the nucleus...the authors demonstrated that cytoplasmic volume is sufficient to increase nucleus growth". .
  12. . for ultra anaerobic purposes ? If serotonin does not exhaust you, it makes you stronger https://sci-hub.tw/https://doi.org/10.1113/JP277317 The SSRI intake resulted in a stronger force produced during a single maximal voluntary contraction. However, during repeated maximal voluntary contractions, the force produced and the time to exhaustion were reduced compared to individuals who ingested a placebo. To figure out if the fatigue observed in subjects who took paroxetine had a central or a peripheral origin, the authors used the superimposed twitch method. This technique consists in measuring the extra force produced by an electric chock applied on the motor nerve during maximal voluntary contractions. The amplitude of the superimposed twitch reflects the inability of the central nervous system to activate the muscle. Before fatiguing contractions, the superimposed twitch was smaller for subjects who took paroxetine. However, it became bigger after repeated maximal voluntary contraction. Since paroxetine did not change the contractile properties of the muscle, the authors concluded that the supplement of fatigue occurring after SSRI intake was purely central. .
  13. dr. frankenstein

    Testosterone Prevents Hairloss?

    . Topical JAK inhibitors .
  14. dr. frankenstein

    New Member. Amphetamine Neurotoxicity & Rehab

    posted sometime ago Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects https://www.nature.com/npp/journal/v42/n10/full/npp201795a.html Amphetamines (AMPHs) are globally abused. With no effective treatment for AMPH addiction to date, there is urgent need for the identification of druggable targets that mediate the reinforcing action of this stimulant class. AMPH-stimulated dopamine efflux is modulated by protein kinase C (PKC) activation. Inhibition of PKC reduces AMPH-stimulated dopamine efflux and locomotor activity. The only known CNS-permeant PKC inhibitor is the selective estrogen receptor modulator tamoxifen. In this study, we demonstrate that a tamoxifen analog, 6c, which more potently inhibits PKC than tamoxifen but lacks affinity for the estrogen receptor, reduces AMPH-stimulated increases in extracellular dopamine and reinforcement-related behavior. In rat striatal synaptosomes, 6c was almost fivefold more potent at inhibiting AMPH-stimulated dopamine efflux than [3H]dopamine uptake through the dopamine transporter (DAT). The compound did not compete with [3H]WIN 35,428 binding or affect surface DAT levels. Using microdialysis, direct accumbal administration of 1 μM 6c reduced dopamine overflow in freely moving rats. Using LC-MS, we demonstrate that 6c is CNS-permeant. Systemic treatment of rats with 6 mg/kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMPH-stimulated dopamine overflow and AMPH-induced locomotor effects. Finally, 18 h pretreatment of rats with 6 mg/kg 6c s.c. reduces AMPH-self administration but not food self-administration. These results demonstrate the utility of tamoxifen analogs in reducing AMPH effects on dopamine and reinforcement-related behaviors and suggest a new avenue of development for therapeutics to reduce AMPH abuse.
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