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VirtualCyber

Niacinamide Riboside

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NAD is all over the news as anti aging pill, even in my local news.

http://www.dailymail.co.uk/news/article-6121913/New-technique-humans-live-150-regrow-organs-price-coffee-day.html

 

the article references a human trial, and I cant find it in pubmed.

 

maybe its this research they are referring too:

https://www.ncbi.nlm.nih.gov/pubmed/29570999

a full text for the above or for this:

https://www.ncbi.nlm.nih.gov/pubmed/29577959

would be a good place to dig.

 

I remember telling myself to go back to NAD+, so they reminded me.

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On 5/20/2016 at 3:07 PM, Sanction said:

PQQ, oxaloactate and Toremifene

Wow, you're the Canadian Elle

So what happened to your six month trial of NR?

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1 hour ago, Elle said:

Wow, you're the Canadian Elle

So what happened to your six month trial of NR?

I stopped it, but still take PQQ and oxaloacetate.

Since then I've tried NMN twice (Nicotinamide Mononucleotide). It's so expensive that I didn't reorder, but I think I notice a subtle decrease in energy and motivation since stopping.

Of course, that could have any number of causes.

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I wonder if there's a reliable blood test that can tell the difference WRT mito support and protection. I mean, this is why all those mainstream media articles on Sinclair from the last week had me enthralled, because they speak about reducing the age of organs by 20 years. how did they measure that? in the march research the talk about aortal stiffness tests but say there was no statistically significant improvement

can anybody please spot which research was that? my scurrying of Pubmed did not amount to a human trial like reported in the news. 

 

 

Also, about dosing - the news pieces also mentioned it costs "as much as a cup of coffee a day".  well the march trial (https://www.nature.com/articles/s41467-018-03421-7) had the dosing at 500mg X2 ED 

The Niagen when you buy the 3 pack or big bottle costs 105$ for 90 servings of 250mg. that's 22.5 days of 500 mg X 2 ED, so we're talking 5$ a day. that's an expensive cup of coffee.

 

and I don't think the march research is the one I'm looking for, because they did not really got good results that would make the media gush, and Sinclair that is referenced in all the news items is not signed on this one:

 

To gain exploratory insight into potential benefits of NR supplementation on other domains of physiological function in healthy middle-aged and older adults, we assessed a wide variety of outcomes indicative of metabolic function, motor function, and exercise capacity/performance. Total energy intake and expenditure, oxidative fuel source (carbohydrate vs. fat), and physical activity patterns were not affected by NR (Supplementary Table 7). Likewise, we observed no difference in body mass, body mass index (BMI) or percent body fat compared with the placebo arm (Supplementary Table 7) and no differences were observed in measures of glucose or insulin regulation (Supplementary Table 7). Finally, there was no effect of the intervention on overall motor function (Supplementary Figure 2), maximal exercise capacity, as assessed by VO2 max and treadmill time to exhaustion (Supplementary Figure 1A, B), or on markers of submaximal exercise performance (Supplementary Figure 1C−F).

 

EDIT:

it seems the human trials have not concluded yet, although he raves about the effects on his father:

http://www.dailymail.co.uk/news/article-6121913/New-technique-humans-live-150-regrow-organs-price-coffee-day.html

 

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On 10/16/2016 at 6:04 AM, STENDEC said:

 

As usual, I have many other factors at work so I can't attribute much specifically to the niacinamide with any confidence but I have actually noticed that the growth of my ear hair has slowed dramatically...

 

So, is there a possible MoA for this?

...and does it work for nose hair?

 

*adds to cart*

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On 9/8/2018 at 1:20 PM, Elle said:

Also, about dosing - the news pieces also mentioned it costs "as much as a cup of coffee a day".  well the march trial (https://www.nature.com/articles/s41467-018-03421-7) had the dosing at 500mg X2 ED 

The Niagen when you buy the 3 pack or big bottle costs 105$ for 90 servings of 250mg. that's 22.5 days of 500 mg X 2 ED, so we're talking 5$ a day. that's an expensive cup of coffee.

 

I don't know what it's like in other parts of the world. But in the US, spending $5 on coffee is "normal."

 

Stupid...but commonplace. Starbucks is often referred to as "Fivebucks."

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So, my conclusions is that this probably would be effective only in doses that are 5-15 times those that the current product recommends....

 

Anyone up to try and source bulk NR. now's the time to pull some strings with suppliers if you may have, I'm looking at alibaba and it seems that Chinese sources are abundant emailed some of them for a quote on a K. one year at 2 grams for me and my wife (both 44 y/o) would seem like a good test. especially if a can get a Pulse Wave Velocity home test some how for progress.

 

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1 hour ago, Niflheim said:

97% pure but 21% "content"? 

Hmm. From Sigma Aldrich:

" The absolute amount of correct peptide in a sample is the product of the peptide content and the peptide purity. "

The rest must be stuff like water, filler

https://www.sigmaaldrich.com/life-science/cell-biology/peptides-and-proteins/peptides-proteins/technical-resource/explanation-of-peptide.html

 

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