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Growth Factor

Toxic effects of ketamine on HPTA

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Abstract. – OBJECTIVE: In this paper, we focused on the toxic effect of ketamine on the reproductive system in male rats and its underlying mechanisms. MATERIALS AND METHODS: Rats were randomly allocated into four groups (n=10), i.e. a control group and 3 ketamine groups (high-dose, middose, low-dose). Animals in the ketamine groups received an intraperitoneal injection of ketamine (20, 40 or 60 mg/kg) every 3 days for 7 times. Control rats were injected with normal saline instead. To investigate the disruption potential on the hypothalamic-pituitary-testicular (HPG) axis, the relative hormone levels in serum and mRNA expressions for some reproduction-related genes in reproductive organs were evaluated. RESULTS: Ketamine significantly decreased the serum concentrations of testosterone (T), inhibin B, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Meanwhile, the mRNA expressions of GnRH in the hypothalamus, GnRH receptor, LH-β and FSH-β in the pituitary, and LH receptor and FSH receptor in testes were also significantly inhibited by ketamine compared with the control (p<0.01). CONCLUSIONS: These results demonstrated that the ketamine had a toxic effect on the reproductive system via breaking the HPG equilibrium.


In reading the study, I realized I have no idea how well mice model the HPTA axis. Nonetheless, they looked at various metrics and all seemed to suggest the thesis that ketamine had a dose response effect on inhibiting testosterone production. 


So beware! If you're stuck in a crossfitters body and taking ketamine, there may be a way out for you

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