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  2. So as we start to come out of this thing, I am hopeful that there can be some objective analysis of efficacy of some of the public health responses that were put in place....there will be no shortage of data. I've been watching Florida and California as a close (but not admittedly not perfect) matched case study because they have similar large populations, climates, population densities, ethnic diversities, etc. but took very different approaches in terms of restrictions on business, masks, stay-at-home orders, etc. CA has had one of the strictest and longest-lasting bu
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  4. True. Although there's a much better chance of that happening if it is FDA approved for the indication. I am not at all surprised that an insurer would refuse to cover an expensive brand-name drug for off-label use.
  5. Being approved for a purposed doesn't mean being approved by an insurance company though. We'll see. I couldn't get liraglutide covered at 1.8mg, and I doubt I'd get the 2.4mg version of semaglutide covered if it were to get approval. That I'm getting covered for either in the US with PPO insurance and not being diabetic is remarkable, actually. I'll keep my fingers crossed that they don't change their minds. lol
  6. FWIW, I've noticed/perceived some benefits from Curamed brand curcumin products -- mainly better digestive health 'feel' (I have relatively sensitive stomach so to speak), and it seemed to help with hangovers mentally and physically.
  7. My curcumin has always helped me in one special and specific way: it controls my hidradenitis suppurativa. WHen I don't take curcumin, and I get into a cycle where I have boils everywhere-or like this last year where I have several constant boils in the same place-curcumin usually works like a charm. I added it back to my daily stack and like magic, my irritating boils that had been bugging me for 6 months straight disappeared.
  8. Nice updates guys. I am taking Tongkat and TUDCA twice daily in the morning and afternoon, and then I take Vitamin D, Vitamin K, and fish oil once daily with a meal. My stack is about as simple as it has ever been and I am feeling really good while taking it.
  9. Do you feel like the curcumin is doing much for you? I always think back to that classic Ex Dubio thread about the promise of curcumin and the shortcomings of its actual use.
  10. https://blogs.sciencemag.org/pipeline/archives/2021/02/15/glp-1-and-obesity
  11. Aging study (and in young subjects ? I to II (more hypertrophic potential Type II) Eicosapentaenoic acid changes muscle transcriptome and intervenes in aging-related fiber type transition in male mice https://journals.physiology.org/doi/full/10.1152/ajpendo.00184.2020 Age-related sarcopenia is associated with a variety of changes in skeletal muscle. These changes are interrelated with each other and associated with systemic metabolism, the details of which, however, are largely unknown. Eicosapentaenoic acid (EPA) is a promising nutrient against sar
  12. @STENDEC I was thinking about my supplement scope creep just the other day. Perhaps it's something about being cooped up, but really I think it's been trying to do anything to improve my health and condition while the pandemic rages on. AM Meds/Supplements Dose PM Meds/Supplements Dose Boron 9mg Boron 9mg Olive Leaf Extract Olive Leaf Extract Vitamin C 1g Vitamin C 1g
  13. So now this is the 2021 version and my supplement stack, which had dwindled to just a few things, has experienced some serious creep... BID Berberine Glucosamine ALA Tongkat Ali TUDCA Magnesium Ecdysterone EPA Once Daily Aspirin OLE Vitamin K/D Omega 7 Zinc Potassium
  14. Interview with Michael Ristow a German MD who authored the study referenced above and specializes in metabolic biochemistry and is a notable critic of the free radical theory of aging. http://geroscience.com/glucosamine-the-new-metformin-interview-with-dr-michael-ristow-part-ii/
  15. Glucosamine promotes longevity by mimicking low-carb diet, study finds Science News April 8, 2014 FULL STORY Glucosamine has been freely available in drugstores for many decades. It is widely used to treat arthritis and to prevent joint degeneration. Moreover, glucosamine is known to delay cancer growth. In addition, glucosamine reduces metabolism of nutritive sugars, as was already shown some 50 years ago. In 2007, Michael Ristow showed that too much nutritive sugar shortens the lifespan of roundworms, a widely studied model organism in aging research. Conversely, impairing carb
  16. ...it would be nice to play with some combinations https://www.faa.gov/about/office_org/headquarters_offices/avs/offices/aam/ame/guide/media/diabetesmeds_acceptablecomb.pdf
  17. Well part of the problem is that there has been little in the way of effective treatments short of surgery which is generally covered. FDA indicated weight loss drugs are generally covered by insurance, just don't work very well. If profit was the only motive, covering the cost of a drug that led to a 15-20% reduction in BW in obese individuals would be a no-brainer. That's the problem. No insurance company is going to cover a $1k/month drug that isn't FDA approved/indicated for the condition it's being used for. Rationing, whic
  18. The 1.8mg dose was indicated in research, though they may not have pursued on-label guidelines. Obesity is ridiculously expensive to ignore and not treat. Yet insurance companies continuously pursue short term profit over long-term good. It's yet another function that in *theory* a nonprofit or government should be able to take over and administer for the better of the people. I know you'll totally disagree, but your rational libertarianism is not shared by the capitalist corporatists who run industries. Just the pursuit of profit.
  19. Obesity is expensive though. Moral failings aside, it would seem to be in the financial interest of the insurer to pay for effective treatments. Liraglutide isn't FDA indicated for weight loss, even though it works. I think it is going to be hard for insurers to refuse to cover a drug for use in accordance with it's FDA indication, especially if there's no alternative.
  20. Liraglutide is also covered for lower dosages for non-obesity purposes, but not covered for the 1.8mg (I think that's the anti-obesity sweet spot iirc) dosage. So most insurances will cover it for A1C or bloodsugar purposes, but as soon as you come anywhere near the anti-obesity dosage, the clamp comes down. We as a society preach the anti-obesity song and dance, but we put up roadblocks to obese people fixing themselves as if losing weight was a fucking vanity project and the drugs cover up their moral failings.
  21. It seems to me that it would be a slam dunk for the treatment of obesity. What a huge market that would be.
  22. Liraglutide, which is a similar drug, is FDA indicated for obesity already and, I presume, covered by at least some insurance plans for that use? If Novo Nordisk can get this higher dose of semaglutide FDA indicated for the treatment of obesity, maybe the insurance landscape would change.
  23. AFAICR the female hormone panel is the one you should be choosing. Check out the internet for potential discount codes...I think maybe Sten Efferding and a few others have them.
  24. I think the private MD labs panel is a good place to start. My guess is you'll find nothing remarkable but having a decent baseline isn't a bad idea.
  25. The 90 day cost for this to my insurance is reportedly $2200, and that's at 1mg/wk. So that works out to almost $200/mg. Assuming no insurance covers the anti-obesity dose (they won't), that's more than $400 per weekly injection. Perhaps in 10 years when semaglutide injectable becomes generic (assuming that they don't reformulate it to somehow protect their market), it would almost be affordable, but even then, I doubt it. When obesity is made into a normal condition to be treated and not moralized about, maybe these drugs will be potentially life-altering for folks. Until then, i
  26. So I'm 35, haven't run anything in over a year, and I'd like to for once in my damn life do something right wrt to my health. Injuries are happening all the damn time from jiu-jitsu, plus I'm just curious. https://www.privatemdlabs.com/lp/female-hormone-testing.php Also a list of labs here that has my eye.. https://www.directlabs.com/bengreenfield/OrderTests.aspx I think this was recommended on here before. I'd like to continue doing more functional lab tests for gut health, nutrient status and all that good shit, but hormones is where I'd like
  27. Sci-Tech Daily's take on this: One third (35%) of people who took a new drug for treating obesity lost more than one-fifth (greater than or equal to 20%) of their total body weight, according to a major global study involving UCL researchers. The findings from the large-scale international trial, published on February 10, 2021, in the New England Journal for Medicine, are being hailed as a “gamechanger” for improving the health of people with obesity and could play a major part in helping the UK to reduce the impact of diseases, such as COVID-19. The drug, semaglutide,
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