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  2. Drug reverses age-related cognitive decline within days by University of California, San Francisco Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome , prevent noise-related hearing loss, fight certain types of prostate cancer , and even enhance cognition in healthy animals.
  3. Last week
  4. inH2O, yes. I missed that. I didn't pay enough attention to 'psig' I guess.
  5. Ive seen it mentioned on various forums before, but I personally never put too much stock into the idea of partnering class 1 & 2 AAS. As an example, Test + Tren + Mast is often regarded as the gold standard for a UG AAS cycle, but consists of only Class 1 AAS.
  6. We know that spending hour after hour sitting down isn't good for us, but just how much exercise is needed to counteract the negative health impact of a day at a desk? A new study suggests about 30-40 minutes per day of building up a sweat should do it. Up to 40 minutes of "moderate to vigorous intensity physical activity" every day is about the right amount to balance out 10 hours of sitting still, the research says – although any amount of exercise or even just standing up helps to some extent. Article
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  8. It appears that CPAP pressure ratings are typically given in cm-H20 not psi...with the highest pressures available topping out at about 25 cm-h20 which is about the same pressure as the natural gas coming out of your stove...only a fraction of a psi. So I don't think CPAP will work for telomere lengthening even with oxygen.
  9. Probably not. But close. I run at 17. I'm sure folks run higher than I do.
  10. But I am guessing that CPAP pressure is not running around 30 psig is it?
  11. I was getting hyperbaric backwards and thinking something like a hypoxic tent.
  12. note: People with breathing issues have CPAPs that connect to O2 supply. It's just that you have to have emphysema or other serious difficulty to have a concentrator or bottle.
  13. Not unless their CPAP machines are juiced up and hooked up to an oxygen canister. These subjects were in a hyperbaric chamber set to 2ATM and then breathing pure O2 for an hour and a half via mask several times/week
  14. Maybe I'm oversimplifying here, but shouldn't this mean those with sleep apnea exhibit increased telomere length?
  15. SARS-CoV-2 Infection Among Community Health Workers in India Before and After Use of Face Shields M. Emmanuel Bhaskar, MD1; Santhanam Arun, MBBS2 JAMA. 2020;324(13):1348-1349. doi:10.1001/jama.2020.15586 Coronavirus Update With Michael T. Osterholm, PhD, MPH The transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be predominantly through respiratory droplets from infected persons in close proximity to uninfected persons,1 although airborne transmission may also play a role.2,3 Face shields have been proposed to prevent transmission in the commun
  16. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial Yafit Hachmo1, * , Amir Hadanny2,3,4, * , Ramzia Abu Hamed1 , Malka Daniel-Kotovsky2 , Merav Catalogna2 , Gregory Fishlev2 , Erez Lang2 , Nir Polak2 , Keren Doenyas2 , Mony Friedman2 , Yonatan Zemel2 , Yair Bechor2 , Shai Efrati1,2,3,5 Abstract Introduction: Aging is characterized by the progressive loss of physiological capacity. At the cellular level, two key hallmarks of the aging process include telomere length (TL) shortening and cellular senescence
  17. Really good analysis of the current state of the science when it comes to mask-wearing in a community as a means of preventing the spread of disease. The TL;DR version is that masks seem to work in the lab but don't have a significant protective effect when used in real-world conditions. In controlled laboratory situations, face masks appear to do a good job of reducing the spread of coronavirus (at least in hamsters) and other respiratory viruses. However, evidence shows mask-wearing policies seem to have had much less impact on the community spread of COVID-19. Why th
  18. I came to the same conclusion yesterday when my back went into a total spasm for eight hours....looking forward to some rest next week and good eating. Careful with the eggs.... 😐 https://www.sciencedaily.com/releases/2020/11/201115101249.htm
  19. doi: 10.3109/15563650.2010.495348. Colchicine poisoning: the dark side of an ancient drug Yaron Finkelstein 1, Steven E Aks, Janine R Hutson, David N Juurlink, Patricia Nguyen, Gal Dubnov-Raz, Uri Pollak, Gideon Koren, Yedidia Bentur Affiliations expand PMID: 20586571 DOI: 10.3109/15563650.2010.495348 Abstract Introduction: Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clea
  20. I think this is what I've come up with on my own, too. It makes a bit more sense, now. I'm enjoying not doing a hardcore IF several days per week-eggs are good, man. So I'm having breakfast a few days per week-maybe I'll shift to looser weekends than weeks. I'm trying to integrate more Dumbbell work since I got my DBs. I figure that will help with the furnace, too. Need a bit more protein intake overall. With the realization that I was pretty much grinding myself to dust, yesterday I had a hamburger (bun and all) with an egg, and 3 additional fried eggs for breakfast. Then I had
  21. This is where the classic zig-zag sort of diet (CKD/Carb Cycling/PSMF) comes in Sam...feast enough to stoke the fires and then cut way back for a bit, just long enough to drive fat loss but not long enough to shut down your metabolism...rinse and repeat. If you can make it work with your family/lifestyle, I think a generally low carb 5-2 diet with the 2 being essentially PSMF days would likely work pretty well.
  22. Any tips? I have never maintained anything resembling a healthy fatloss diet for more than a few minutes at a time. I find myself having lost over 60 pounds, though, so I've maintained a diet for many months. As you all know, I have been following a lazy or dirty keto diet, so high protein and fat. Low(er) carbs-probably 30-50 on good days and closer to 100 on looser days. Kcals are pretty low, but ~2k-ish. Recently, I've been getting cold. Deadass fucking cold. Chilled to the bone. Cold when my wife and children are not cold. My body temp has been steadil
  23. I did this actualized version of division in Androgen Receptor (AR) affinity of Steroids. What you think about? Class 1 and Class 2 Anabolic Steroids: Of the countless ways that we can divide androgenic anabolic steroids (EAA's), we can divide by their affinity with the Androgenic Receptor (RA). AR is a soluble protein that acts on cell transcription, has nuclear reception activated by androgens (Testosterone and derivatives) in the cell's cytoplasm and moving to the nucleus. He is responsible for male sexual differentiation. It acts mainly on tissues such as musculos
  24. Really good analysis of this Danish mask study. https://www.medpagetoday.com/blogs/vinay-prasad/89778 I find it really chilling that some, often the ones who have been chanting "follow the science" all along have openly turned to social media and have criticized the authors of the study and the journal for publishing the results...
  25. As I suspected. A total of 3030 participants were randomly assigned to the recommendation to wear masks, and 2994 were assigned to control; 4862 completed the study. Infection with SARS-CoV-2 occurred in 42 participants recommended masks (1.8%) and 53 control participants (2.1%). The between-group difference was −0.3 percentage point (95% CI, −1.2 to 0.4 percentage point; P = 0.38) (odds ratio, 0.82 [CI, 0.54 to 1.23]; P = 0.33). Multiple imputation accounting for loss to follow-up yielded similar results. https://www.acpjournals.org/doi/10.7326/M20-6817 “O
  26. In the second presentation, also published Sunday in the Journal of the American Medical Association, researchers found that omega-3 fatty acid supplements did not reduce cardiovascular risk. This was also a double-blind randomized trial that compared the health of patients who took a high dose omega-3 supplement with those who took a placebo of corn oil. The 13,078 patients in this study were being treated with statins and had a high cardiovascular risk, high blood troglycerides and low levels of the good cholesterol known as high-density lipoprotein cholesterol. The v
  27. Colchicine is typically used in doses of 0.6mg to 1.2mg to prevent gout flare-ups. It's not entirely without side effects, but it's generally well tolerated. More recently, Colchicine has been observed to have some value in prevention of heart disease: More info in the full paper here: https://www.clinicaltherapeutics.com/article/S0149-2918(18)30596-4/pdf . The authors suggest that 0.5mg/day of Colchicine could have significant value in preventing heart disease, albeit as a second-line treatment. To date, most Colchicine trials have used 1mg/day do
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