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  1. 3 points
    Here, we report that prazoles, approved for use as PPIs, also exhibit potential for antiviral therapy. For this application, the prodrug required conversion inside cells. HIV-1, MAYV, EBOV and EBV replication were tenatoprazole sensitive while DENV, ZIKV and PV replication were resistant. Further testing employing HIV-1 as a model revealed its susceptibility to additional prazoles with inhibition generally correlating to the rate of pro-drug conversion to the active sulfenamide derivative. Full Article
  2. 3 points
    STENDEC

    My new woe: Diabetes or Metsyn+NAFLD

    PSMF Sam. You need to shed 80-100lbs would be my guess....your apnea, dyslipidemia, NAFLD, HTN, diabetes will all likely be gone or significantly improved if your weight was much closer to 200 than 400lbs. PSMF will do it and relatively quickly if you can stick to it. You will need the full support of your wife and kids to some degree as well. Maybe give yourself a single cheat day per week to make it bearable, but you need to intervene dramatically in your metabolism at this point.
  3. 3 points
    OK, so working back up in volume and intensity. GOt back on the Josh Bryant template, though I just can't make 8 sets of life fit into a workout, so I've halved all of the accessory work. I don't need to put on pounds of meat, I just need to keep strong, get fit, and not get fatter. If someone looks at the work from today and thinks it needs more in certain areas, please call it out. Squats 45x10 135x5 185x5 225x5 275x5 315x3x3S Note: I plan on adding more sets here before I add sets to accessories. Leg Press 270x8 360x8 450x8 540x8 Interleaved with: KB swings 70lbsx8x4S Sled Pulls - up and back each rep 165 220 275 330 Leg curls - Individual L/R 35x8 40x8 45x8 50x8 Leg Extensions 90x8 100x8 105x8 110x8 This took exactly as much time as I wanted. I will need to make up the cardio in walking the rest of the day.
  4. 2 points
    Bump. Now that most of us don't have access to a gym, I've been "jogging" a couple of times a week....just a couple of miles and rather slowly but according to this data, I'm doing myself some good. Similar findings from the Copenhagen Heart Study although they determined a U shaped dose response. Compared with sedentary nonjoggers, 1 to 2.4 h of jogging per week was associated with the lowest mortality (multivariable hazard ratio: 0.29; 95% confidence interval [CI]: 0.11 to 0.80). The optimal frequency of jogging was 2 to 3 times per week (HR: 0.32; 95% CI: 0.15 to 0.69) or ≤1 time per week (HR: 0.29; 95% CI: 0.12 to 0.72). The optimal pace was slow (HR: 0.51; 95% CI: 0.24 to 1.10) or average (HR: 0.38; 95% CI: 0.22 to 0.66). The joggers were divided into light, moderate, and strenuous joggers. The lowest HR for mortality was found in light joggers (HR: 0.22; 95% CI: 0.10 to 0.47), followed by moderate joggers (HR: 0.66; 95% CI: 0.32 to 1.38) and strenuous joggers (HR: 1.97; 95% CI: 0.48 to 8.14). The findings suggest a U-shaped association between all-cause mortality and dose of jogging as calibrated by pace, quantity, and frequency of jogging. Light and moderate joggers have lower mortality than sedentary nonjoggers, whereas strenuous joggers have a mortality rate not statistically different from that of the sedentary group. FFT
  5. 2 points
    habit

    How to get TRT with normal test ratings?

    Update: So I had some bloodwork come back about a week ago. Total test............29! Anyone who says SARMS/LGD doesn't shut you down pretty hard is dreaming. I was on a relatively low dose of 5migs for 8 weeks and the bloods were taken the last week. Also, my fasting blood glucose was 109, which is considered pre-diabetic. My diet isn't great (some refined carbs but no outright sugars, enough fiber) and I compared it to last year which was 99, the upper limit of "normal". I'm genetically predisposed to type II so I have to be careful. Also wondering if the MK had just enough of an effect in this area as I have heard it has (about a bump of 5 for most people, which is consistent). Either way for PCT I have continued MK as a bridge, taking a day or two off here and there for insulin sensitivity issues. Also began IF again as I know it can boost T. I know it won't do much for hypertrophy but hopefully help me retain LBM in a deficit (and without heavy training as gym is closed obviously). I am down about 5lbs , which I hope was the water but am still getting plenty of "juice" comments at work, which I got before my cycle anyway, but let me know something worked. Traps/Delts in particular grew nicely. All in all, if I can get my test back up to ~600ish, knock on wood, for a test in 3 months and stay at 175 I'd say it was successful and I will revisit SARMS in the form and RAD140 for next go around...
  6. 2 points
    The supply chain will resolve itself in a couple of weeks because the issue isn't a problem of supply....there's plenty of meat and bread and milk. There's been a huge uptick in demand but nothing structural has changed....there are not suddenly twice as many people living in the Bay Area. Eventually, people will run out of freezer/refrigerator/shelf space and have to start consuming all the stuff they bought rather than buying more. We're going to be okay Sam.
  7. 2 points
    In the last 2 years, my wife and I finally got to start breathing in between paychecks. We started being able to set aside cash for emergencies and for our kids and their trips and projects and whatnot. We've been steadily paying off bills and credit cards. My car is only a few payments away from being fully owned by me. We've got cash on hand, now. Things have been looking really good to pay off more stuff, save more money as other bills are paid off, and maybe get ourselves into a situation where we can actually move in a year or two into a place we want to be when our youngest is ready to move to middle school. That has all pretty much evaporated. My wife's largest contract just ended. That's the contract that pays the difference that the $900 rent increase made to us. Fine. It'll probably be a few weeks before she returns, unless the doctor folds-which is also a possibility; given the way things are going. Her other contracts could easily go away temporarily or permanently as well. I have a promotion that I have been working on, and there are annual company raises that are in doubt. Hell, my bonuses are probably zeroed out, too. My RSUs might as well be printed out and used for toilet paper-and that's shit I was counting on being there when the time came. I'm so very, very disappointed. I'm doing my best here, but sonofabitch. I know that most of these things will either resolve, not come to pass, or change in-flight. I know that. But still-I can't shake the loss that was me standing on the edge of some of the best footing I've had in decades. We're seeing scarcity-literal scarcity-in my area. We couldn't find meat(any meat-no ground beef, no chicken breast, no whole chickens, no pork). We ended up hitting multiple stores and even then, had to improvise. I've never had to live in this way. I'm hoping the supply chain irons itself out, because this feels BAD. The US's trajectory wrt illness numbers, as well as serious cases looks BAD. Basically, we're looking worse than some of the less modern and less civilized nations. It will probably continue to get bad until people get over their pride and realize that they are fucked if they continue to do beer bongs on the beach with random people, or go to the gym. It's a guarantee to get worse unless our leaders stop feeding bullshit to their constituents. I broke down yesterday. This is all too much for me. I'm having to limit my access to the internet, now. The data of the pandemic is great. My first love is pandemic illness from a subject standpoint (odd obsession, but it is what it is). Hell, I've said for decades that this was coming. But now here it is. It's awful. Always knew it would be. Re-reading this, it's like a first-world karen whine. I'm almost too disgusted to press the "submit Reply" button.
  8. 2 points
    I had middle-of-the-night anxiety last night, which is unusual for me. I figure most people are going through shock, and that shows up in a hundred different ways. In a few days we will have adapted somewhat. Briefly, here's how I deal with the anxiety to move the adaptation process along: - breathe into the lower abdomen - focus on the uncomfortable sensations for a while (they are mostly located in my torso) - ask the emotions what they want me to understand - decide on some concrete action I can take - remind myself that I am fine here and now, with food, shelter, indoor plumbing...
  9. 2 points
    Related Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro. Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect. FFT
  10. 2 points
    nightop

    Something Clever (by Nightop)

    Random observation: ON's Hydrolyzed Whey Chocolate Mint (30g) with dextrose powder (30g) in 16 oz. of water is absolutely delicious.
  11. 2 points
    Emperor G_D

    Old Powerlifters don't just die...

    In a country with no real social safety net. Where people get paid a minimum wage for a shit job like "desk clerk", and can barely pay their fucking rents, I can see where this comes from. They will open our gyms, and make our burgers and fries, and serve us mocha-frappu-whatevers, because they don't get time off, or can't afford to be sick again, or whatever. This is as much a symptom of the US's core issues as it is about a virus...
  12. 1 point
    Yes, I completely expected a reduction, but maybe it was a bit more than anticipated. Current broscience doses are 10migs, but we all know how that goes. Next go around I might try 2.5. I have labs scheduled in about 6 weeks so we will see...
  13. 1 point
    Burton

    Old Powerlifters don't just die...

    The problem with life is that life now a days is just a shit proposition. I know there's always that contingent that says "but life is better than it has ever been". And that's true in a lot of ways but just because life was total ass in the past centuries doesn't mean it can't be better and that we shouldn't be allowed some malaise. I could argue serfdom wasn't so bad. Their lives were hard during the planting and the harvest but they had much more free time the rest of the time. But medicine and such was obviously orders of magnitude worse. But in America it's out of the reach of entire classes of people so there's that. My comment isn't even a woe is me one. I still have a job in an essential industry. We'll keep it America centric but what most people don't seem to understand is that millions in this country, potentially tens of millions are gonna be destroyed by this. This has the potential to wipe out a whole generation, a generation who was barely holding on in the first place. So many of us made decisions when we were 17 based on what we were told what would allow us to build a life. We just didn't know they were lying. If I were to do it over I'd go into the service when I was 18, put in my time and get the GI Bill. But that pushed back against by everyone I was supposed to trust. It's just all shit and bootstraps in the overwhelming majority of cases are a lie. I'm really hoping for accelerationism at this point. Of a societal epiphany or catastrophic collapse. I don't care which one if I'm being honest
  14. 1 point
    Burton

    Old Powerlifters don't just die...

    Sorry to hear, buddy. It's a crushing experience when you're right on the cusp and then the rug is pulled out from under you. I was in that spot last fall and then Adrienne lost her job. I was like two months away from being able to start paying my student loans back with the option to start saving additional money with the eventual goal of just saving up about 35% of the balance and then just buying them out and being free. She had 3 promising interviews this last week one of which she felt she was gonna get and now the whole fucking state is shut down and these non profits that do their events are probably gonna have events cancelled so even if she was the top choice for the one position, who knows if that job or for that matter, even the organization will exist in 3 months. It's just one big scam it feels like in this country. You do everything right. I paid my student loans for almost 15 years and then I have a hard year and they're emailing me once a day and calling 3 times a day threatening to take me to court. They've made as much money off me as they loaned plus about 10% but my balance is now back to more than the original value. My missed payments with them have tanked my credit rating by literally 200 points so if I ever need to buy anything like a car I'm fucked. Hell, I'm even afraid of trying to rent a new place with my snazzy 545 credit rating which used to be 755, which we are going to have to do in the very near future, like in 2 weeks as we may finally have a way out of our slumlord situation before lease end. I remember seeing about 2 weeks back the notification from the college in Norway recalling their students from countries with inadequate health care infrastructure should return immediatley and they specifically mentioned the US. I can't help but shake the feeling this place really is a second world country with a fancy veneer. Anyway, I hope you guys pull through this okay and get back on track as quickly as possible.
  15. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    20/03/21 DEADLIFT C2W2 DOUBLE PAUSE DEADLIFT 225x4 315x3 405x3 500x2 <-- RPE 10, some ugliness, but good speed. Should have used lower weight (495?) CAT DEADLIFT 390x4x4 First set was bad, last three sets were very explosive SSB PIN GM 225?x8,8,8 (unsure if bar is 45lbs or heavier; rogue ssb with plastic handles) Forgot to do abs today thinking I was going to be doing something not conducive to protecting myself against coronavirus. As a sidebar, I did actually set up 2 dating apps on my phone, finally, after all this time. Of course this is a terrible time to do it if for no other reason than outside places are not open (in addition to the higher risk of contracting AND spreading disease). I'm running a bit of an experiment as well by setting up my bumble to be oriented for more substantive relationship-seeking people, while my tinder looks like it's more about hookups, including not just a different profile but different sets of pictures. To nobody's surprise, the amount of matches I get on tinder (10 in under 12 hours) are orders of magnitude larger than what I've gotten on bumble (3 in about 10 days). I wonder what are good ways to do dating during such times. bumble recommends something called virtual dating, and I've seen a friend hold a virtual happy hour with her coworkers, so maybe that is the way to go.
  16. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    Sorry, missed your reply due to the active Coronavirus thread. I think right now I'm set if shit hits the fan. My roommate actually had a pullup bar already, so I've got a pressing and pulling exercise. I could probably even rig the dip stand with some chairs to do inverted rows if I wanted to. I've got bands for shoulder health stuff, and for legs I'd probably do walking lunges for distance, or jumping lunges, or even jumping squats. I dont have any coordination or strength to do pistol squats I bet. I guess for you, you'd have some pushup variations you could work with, especially given the slamball and dumbbells for grip variations. Remember, too, you can do those shoulder pushups to hit the shoulders But for the time being, the few Golds in my area are also allowing us to requeue if the line is not full, so I was able to get a deadlift workout in yesterday, for instance.
  17. 1 point
    Emperor G_D

    Old Powerlifters don't just die...

    Ah, to be blissfully ignorant of what war-time or depression era felt like. I haven't been doing much. Trying to hold on for dear life. Trying to understand how different things are, and how they will be, and how they've changed-probably-permanently or semi-permanently. I'm WTFing on the regular right now. I really wish they would roll out a test for us to find out if we have or have had COVID. That alone would would reduce most of my fears to about zero. Then I could concentrate on important shit. But no, I spend every day indoors, mostly freaking the fuck out because this is a genuinely honest time to do so. I have been getting some walks in, walking with my kids, but not much else. I have 25lb dumbbells, some bands, a 20lb slamball, and that's about it. I have a prowler, but I can't set up or use that anywhere near my home without violating just about every part of isolation. I haven't figured out what to do for exercise yet. I just can't spend the fucking mental energy. I went to my neuro 2 weeks ago, I weighed 351 fully dressed, so about 348. Tuesday I weighed in at 346. This morning I weighed in at 338. The ritalin is a big help with my eating habits. Instead of obsessing about eating when I'm hungry-really, I've been obsessing about this shit for years-I no longer have "MUST EAT" in my mind. I'm on day 2 at .6mg Victoza. The Dr. wanted me to titrate up to 1.8mg over 3 weeks, but I'm wondering if there's utility in staying at a low dose until I need more and then moving up.
  18. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    20/03/18 OHP OHP superset CHINUPS 145x8,8,7,7 BWx10,10,10 (skipped 4th set) DIPS SUPERSET BO BB ROWS BWx12,10,10 <-- shoulder was a little bit off, and the dip stand was strange, so limited these for now and emphasized tricep usage) 225x12,12,12 <-- properly situated shoulders for these, really felt them all over my back Well there was my first COVID workout. Took about 40 minutes more or less, which was all I have due to the new protocols in place in my state. 10 people in a gym max, including employees, so they're letting 7 people work out for about 30 mins a piece. Pretty happy with what I got done and appreciate that they're open at all. I think those of us who are active should start brainstorming ways to remain active and keep up resistance training at home as things begin shutting down. I'm already set with pressing as I have a dip stand, and I'm looking to order a chinup bar that can double as something to do L sits, pushups, and maybe some other core work.
  19. 1 point
    nightop

    Something Clever (by Nightop)

    Interesting re:Boron -- thanks. I'm researching glucosamine/MSM products, but wasn't sure if people here have a go-to for that which is most cost-effective or optimal for whatever reason. I think Kimbo has taken or still takes something like this for joint health, but don't know if he's still around on here these days. Unrelated comments/additions that I meant to include above: - I tried a 'PM recovery' supplement that was offered to me for free containing tart cherry extract, boswellia extract, and safflower extract; I had one of the best nights of sleep I can remember having in the past few years, and I've since replicated this finding over several random nights (taking it right before bed). I assume it's the tart cherry doing most of the work along those lines but not sure. Just thought I'd mention it since tart cherry extract seems to have some other interesting and potentially beneficial effects. I'm not using regularly though. - No idea if this is going to make much of a difference, but I've also started doing a set or two of 10-rep free squats, jumping jacks, sit-ups, and pushups about 15-30 min after every non-workout meal, mainly to subtly improve my general conditioning and perhaps for a positive nutrient portioning effect. Does anyone else do something like this? As lame as it sounds, I'm really trying to get my general 'fitness' back after being out of the gym for so long, and short of doing regular HIIT which isn't a good option right now, I've resorted this approach.
  20. 1 point
    nightop

    Something Clever (by Nightop)

    Updated regimen with mostly removals of certain supplements and a few comments/questions at the bottom: Upon waking/first meal (removed vitamin C; fish oil; MCT oil; ginger root -- all taken only sporadically now): - Green tea extract (400 mg) - Vitamin D3 (800 IU) - Calcium (500 mg) - Cayenne pepper (500 mg) With second meal: < nothing so that I don't have to bring anything with me if eating out > Around workout (on training days; removed taurine😞 - Beta-alanine (2 g, pre-workout) - Alpha lipoic acid (300 mg, post-workout) With third meal: - Cayenne pepper (500 mg) - Apple cider vinegar (1-2 oz) - Vitamin K2 (MK7 100 mcg) With fourth meal: < nothing, except sporadic use of MCT oil and/or cacao powder in protein shake > Bedtime: - Metamucil (1 tbsp) - Melatonin (2.5-3.0 mg) - Magnesium (200-400 mg from mag.citrate) Comments: 1) I removed several supplements/doses for simplicity, cost, and because I don't think they were that necessary or beneficial. 2) Training has been much more enjoyable after switching from the HST and UD2 routines to my personal 'hybrid' training split 3) Diet is moderately hypo caloric (~400-600 kcal deficit/day) and will continue that way for another two weeks -- decided to do this because I want to lose a bit more fat. 4) For the first time in my life, I've experienced joint pain and snap/crackle/pop sounds while lifting, which is probably just from age and inactivity for ~10 years.. sigh. Questions: Any recommendations for a combination joint health supplement product (e.g., Osteobiflex-like) that actually makes a difference? I'm woefully ignorant in this area. Should I be taking high and/or more frequent doses of beta-alanine (for exercise performance)? e.g., on non-workout days, 2g x2 or x3 day, etc.? What's the best practice?
  21. 1 point
    Excellent, thanks for letting me know. Please just drop the desert, or substitute it with some artificial sweetener thing. You really have to avoid all extraneous calories at the moment and especially sugars because they spike your insulin and it's a mental thing as well. "What desert? I don't eat that on the day-to-day" That's the way your thinking should change. You might say that lifestyle stuff won't work, sure it won't work as fast as you'd want it to, but if you keep putting oil on the fire, it won't put out, so to speak -- to use a crude analogy. Lifestyle can go a long way and should be in conjunction with medication in your case, yes. But it takes some suffering to go through the adaptation period. As for Victoza this is a good option by your doctor as it can also help with the weight loss. The only issue is that it is quite prone to gastrointestinal disturbances, so it might not get better than metformin in that regard. What happened with metformin exactly? Just diarrhea? There is some research to suggest that the reason one gets such gastrointestinal issues is because of it affecting the microbiome (actually favorably). I'm pretty sure you'll get some disturbance on that front on any drug that affects the microbiome and likewise any lifestyle that involves dietary change. Your bacterial flora will change, and that's bound to give some issues with diarrhea/constipation, etc. You can try and get some Triphala or Amla to stay regular, it's one of those all-rounds that has evidence where it's been shown to reduce fasting glucose and improve lipids. It's usually cheap too. Banyan Botanicals has that. Just my two cents! Hope it helps. Wishing you the best in your recovery! Good to hear on cardio. Keep it up! Hmm, I see. Maybe there are some cheaper options? Not an expert on the market there, I'm afraid.
  22. 1 point
    kassem23

    My new woe: Diabetes or Metsyn+NAFLD

    Optimizing testosterone may help your ADD/ADHD issues as well. It is dopaminergic and can improve concentration. I'd go with a clinic, as most endocrinologists are not familiar with the latest research and will get you on a crazy regimen like 200mg every 2 weeks. Get on a microdosing regimen using insulin needles sub-q, or at the very least a biweekly IM injection regimen. That'll get your levels into a good range and help with body recomposition and insulin sensitivity. What do you do for exercise? What's your cardio like? Have you spoken with your doctor about getting a Dexcom? This may help you A LOT because you get direct feedback based on what you eat. That way you can see if what you're eating is directly helpful or harmful and may improve your own compliance on the diet-plan. My dad is an endocrinologist and is trying it out now, he's not a diabetic but shows signs of pre-diabetes and metabolic syndrome, and he has been incredibly surprised by what food articles that spike his blood glucose. I'd highly suggest getting this or a similar glucose monitor.
  23. 1 point
    Life will be the suck for 120-180 days....then it will be much better.
  24. 1 point
    In my case, I'd have a down test and an up test and a down test and an up test. So I never really had a huge reason to switch. Looks like I will push for switching, now. So my guess is that I'll switch to an endocrinologist to manage that and the fact that I just tipped over into diabetes territory judging by my bloods. I need to lose about 100 pounds.
  25. 1 point
    Emperor G_D

    Mr.Kite is doing 5/3/1

    Ja, willkommen in der Elternschaft!
  26. 1 point
    STENDEC

    Caffeine & Diet

    Caffeine may offset some health risks of diets high in fat, sugar Science News December 20, 2019 A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing the storage of lipids in fat cells and limiting weight gain and the production of triglycerides. Rats that consumed the caffeine extracted from mate tea gained 16% less weight and accumulated 22% less body fat than rats that consumed decaffeinated mate tea, scientists at the University of Illinois found in a new study. The effects were similar with synthetic caffeine and that extracted from coffee. Mate tea is an herbal beverage rich in phytochemicals, flavonoids and amino acids that's consumed as a stimulant by people in southeastern Latin American countries. The amount of caffeine per serving in mate tea ranges from 65-130 milligrams, compared with 30-300 milligrams of caffeine in a cup of brewed coffee, according to the study. For four weeks, the rats in the study ate a diet that contained 40% fat, 45% carbohydrate and 15% protein. They also ingested one of the forms of caffeine in an amount equivalent to that of a human who drinks four cups of coffee daily. At the end of the four-week period, the percentage of lean body mass in the various groups of rats differed significantly. The rats that ingested caffeine from mate tea, coffee or synthetic sources accumulated less body fat than rats in the other groups. The study, published recently in the Journal of Functional Foods, adds to a growing body of research that suggests mate tea may help fight obesity in addition to providing other beneficial health effects associated with the phenolic compounds, vitamins and flavonoids it contains. "Considering the findings, mate tea and caffeine can be considered anti-obesity agents," said Elvira Gonzalez de Mejia, a co-author of the study and director of the division of nutritional sciences at the U. of I. "The results of this research could be scaled to humans to understand the roles of mate tea and caffeine as potential strategies to prevent overweight and obesity, as well as the subsequent metabolic disorders associated with these conditions." In the rats, the accumulation of lipids in the adipocytes was significantly associated with greater body weight gain and increased body fat, according to the study. To determine the mechanism of action, the scientists performed cell culture studies in which they exposed adipose cells from mice to synthetic caffeine or the coffee or mate caffeine extracts. They found that regardless of its source, caffeine decreased the accumulation of lipids in adipose cells by 20%-41%. The scientists also tracked the expression of several genes associated with obesity and lipid metabolism. These included the fatty acid synthase gene (Fasn), an enzyme compound involved in the synthesis of fatty acids from glucose; and the lipoprotein lipase gene (Lpl), which codes for an enzyme that breaks down triglycerides. All of the caffeine treatments, regardless of origin, significantly downregulated the expression of both Fasn and Lpl. In the cell cultures, Fasn expression diminished by 31%-39%, while Lpl expression decreased by 51%-69% among cells treated with synthetic caffeine or the caffeine from mate tea or coffee, they found. In the rats that consumed the mate tea caffeine, expression of Fasn decreased by 39% in their fat tissue and by 37% in their livers, the researchers found. The decreased expression of Fasn and two other genes in the liver evoked lower production of low-density lipoprotein cholesterol and triglycerides in the liver as well, according to the study. "The consumption of caffeine from mate or from other sources alleviated the negative impact of a high-fat, high-sucrose diet on body composition due to the modulation of certain lipogenic enzymes in both adipose tissue and the liver," de Mejia said. "The decreased expression of Fasn and Lpl brought about lower synthesis and accumulation of triglycerides in the adipose tissue." Journal Reference: Fatima J. Zapata, Miguel Rebollo-Hernanz, Jan E. Novakofski, Manabu T. Nakamura, Elvira Gonzalez de Mejia. Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation. Journal of Functional Foods, 2019; 103646 DOI: 10.1016/j.jff.2019.103646
  27. 1 point
    https://www.psychologytoday.com/us/blog/anxiety-another-name-pain/202001/surprising-solution-address-chronic-pain?amp= A Surprising Solution to Address Chronic Pain To master a new language requires a focused commitment for a long period of time. If you wanted to become fluent in French, it would take years of reading books, attending classes, listening to audiotapes, and probably immersing yourself in the culture. Eventually, a new part of your brain would develop that enables you to speak French. This is possible because of the brain’s capacity to change by increasing the number of neurons and connections between them. The brain produces an insulating material, called myelin, and as new connections are made, changes occur in the glial cells. These are the supporting cells of the central nervous system. This process of acquiring new neural connections is called “neuroplasticity,” and your brain changes every second. (1) Not Speaking English You can’t learn French by “not speaking English.” What a ridiculous idea! But what about trying to solve chronic pain by focusing on “not being in pain?” Where is your attention? What is being reinforced? Your brain will develop wherever you focus. By constantly (and understandably) seeking a cure or discussing your pain with those around you, you’re reinforcing the pain circuits. As they become more deeply embedded in your nervous system, you’ll use the creative part of your brain less. In fact, research shows that the brain physically shrinks in the presence of unrelenting pain. Fortunately, it re-expands once you have healed. (2) What You Resist Will Persist One of the core neuroscience-based concepts of solving chronic pain revolves around the current definition that it "… is an embedded memory that becomes connected to more and more life experiences, and the memory can’t be erased.” (3) Once you’ve developed chronic pain, the connections are permanent. The more you fight them, the stronger they’ll become. Continually discussing or pursuing a cure is understandable, but it can also be compared to putting your hand right into a hornet’s nest. Your attention is on the problem and not the solution. So, what do you do? These are some counterproductive practices that keep your pain at the forefront: The endless quest for a cure Frequently discussing your pain or medical care Complaining Gossiping Not being willing to learn new ideas or being open to change An Enjoyable Life What you can do is learn a new language, which I have termed “an enjoyable life.” Since anxiety and anger are basic survival responses, that’s where your brain is programmed to go as the default language. These automatic responses become stronger with age and repetition. To train your brain differently requires a deliberate, long-term, focused effort. The first step in any new endeavor is to create a vision of where you want to go. What do you want your life to look like? Do you want to live in this state of affairs indefinitely? You can’t accomplish anything of significance until you know what it looks like and internalize it. What you’re doing by creating and pursuing what you want is developing a new nervous system within your existing one. It’s like putting a virtual computer on your desktop. As you continue to work on learning the language of “an enjoyable life,” you’ll be paying less attention to the pain circuits, and they will atrophy from disuse. At some tipping point, your pain and anxiety will diminish dramatically—but not by trying to make them drop. It’s similar to re-directing a river into a different channel. It will be slow at first, but as the flow of water is diverted, the force of the water will help create the new channel. Learning the New Language While the process may seem overwhelming at first, you can create changes in your brain and its response to pain. The strategies include: Reconnecting with the best part of who you are Active meditation—placing your attention on a different sensation Re-learning how to play Somatic work—connecting thoughts with physical sensations Expressive writing Re-engaging with familiar art, hobbies, music, dance, sports, etc. Spending quality time with family and friends (53 percent of Americans are socially isolated) Forgiveness—you can’t move forward while you’re hanging on to the past Giving back—there are an endless number of possibilities Listening—it’s more interesting than re-hashing your own views on life Creating your vision in detail of how you want your life to look Getting organized so as to be able to execute your vision Your brain changes every millisecond. The amygdala is part of a series of circuits that encode external stimuli as noxious. In chronic pain, even normally neutral input may be perceived as unpleasant. (4) With mindfulness-based treatments, the amygdala can diminish in size. (5) You have a choice of what part of your brain you want to stimulate to grow. Where do you want to place your attention? What language do you want to master?
  28. 1 point
    Emperor G_D

    Old Powerlifters don't just die...

    Thanks, Ben. He rx'd Ritalin, of course. Well see how it treats me at a low dose. I just need a little more control of myself for a bigger percentage of the day than I have now.
  29. 1 point
    I wouldn't think bupropion would be a first choice anyway. Ritalin/dexedrine/Adderall at a moderate dose. I'm pretty sure those are generally safe to use for epileptics. https://www.webmd.com/add-adhd/news/20190312/adhd-meds-safe-with-epilepsy-study-finds
  30. 1 point
    Sanction

    GF's "CS Goes Pubic" Log

    There's always a balance between taking a higher dose of a med so that you get the effect, but not so much that the sides become intolerable. If that's working for you then there's no need to up the dose
  31. 1 point
    nightop

    Aminophylline

    Bumping this old thread/post because I'm still interested in topical fat loss solutions (despite the endless discussions and arguments about it over the past few decades), and I saw this same study referenced in a separate thread here. Here's a link to the free FT (if it works) of another relevant older paper from one of the same authors: https://onlinelibrary.wiley.com/doi/epdf/10.1002/j.1550-8528.1995.tb00228.x I'm not necessarily arguing for or against potential merits of topical aminophylline, but in the past I've always been more or less a 'believer' (at least conceptually) in topical fat loss agents in the context of hypocaloric diets, assuming any positive effects would immediately reverse upon return to a maintenance or hypercaloric state. Have there been any advances in this area over the past few years? Any new products/ingredients that actually have solid supporting evidence for their efficacy? I doubt it, but wanted to spark discussion anyway if anyone else is interested in this area.
  32. 1 point
    Burton

    Old Powerlifters don't just die...

    It's a fucked up situation too. Everything in our economy is based solely around the next quarter's profits. I can't back this up with facts or a quote or anything but I don't see anything to contradict my feelings. This is honestly a math I think would play. The stock market could take a 25% hit for a couple of years and 2.5 billion would live or the market could make a 10-12% short term return but those 2.5 would die and the long term economy would crater. I honestly wonder what corporate decisions would be made, as it would be a serious debate in this world now a days where everything is driven by the current fiscal quarter. Also, random off thought. Sam, have you seen how mad I've made a few of the centrist libs on David's posts on FB? That shit is wild. They got real pearl clutchy when I questioned Joe Biden's mental health and whether or not he was slipping into senility (for the record, I'm not sure but feel a strong maybe there, but he's definitely not crisp enough to handle a Donald Trump debate barrage). I have to admit that I ended up removing FB from my phone due to me just getting too many "you're a cultist and a delusional asshole" notifications. Don't shake the centrist tree was the lesson I learned there. Too many of his internet friends are like two-three steps away from becoming the fen x equivalent of chuds. I am still laughing about the old lady (like 85) who talked shit and I called her centrist neo lib trash. Then her son came in and threatened to beat me up. I had to eventually block them but the internet is wild.
  33. 1 point
    Emperor G_D

    Old Powerlifters don't just die...

    🔥 🔥 🔥 🔥 🔥 🔥 🔥 100% The question was asked often up front, but who will pay for an extraordinary push to test COVID cases? After enough time and deliberation, these chumps all came up with strong positions on a state level stating that insurances are to cover COVID testing, but that's a PR thing. Our federal admin would have had us pay OOP for the tests and allow the insurances to skate. There literally is no greater good in government or business, today. Well, maybe Bill Gates (ironically), and a few other billionaire capitalists qualify, but not much else.
  34. 1 point
    Burton

    Old Powerlifters don't just die...

    I would hope that I would not choose to do this but I could certainly see a justification for malice if I worked one of those jobs and got sick and to keep going in. If you work at Starbucks, you spend all your days selling shitty coffee to carefree people at 3-7 dollars a pop (which could be anywhere from 0.5-1 hr of your pay after tax). And God help you if you get sick because at best you won't get paid, more realistically you get fired for not coming to work for 2 weeks. So basically you're met with forced labor as a walking infectious agent or homelessness. All while you can't even afford to go to the doctor while you are sick. All because capitalism needs to make a few more bucks. What's the actual motivation to care about not getting others sick? Even if someone who works at Starbucks gets me sick, it's an inconvenience for me in about 999/1000 instances but it's literal life and death for them so why not give creating Carnage a shot? I keep telling everyone who will listen and lots of people who won't that the sickness of capitalism will take us all down with the ship and this whole situation is a great example. I read a quote from someone at the CDC I believe talking about how the government would have to "negotiate" with pharma to guarantee proper pricing to make an adequate profit to get them off their asses to work on vaccines. You know there's rooms full of people across all industries running corporate strategy sessions designed around maximizing corporate profit and how best to exploit the pandemic for maximizing profit and share price. It might not be the verbage they're using but it's the point and everyone there knows it unless they're in the deepest stages of denial. Capitalism will literally let us all die if it can't extract enough value out of us. It'll become the Umbrella corporation if given a chance.
  35. 1 point
    Burton

    Old Powerlifters don't just die...

    Also, I have become Alan, destroyer of worlds. You should get him a tombstone with that carved into it. Not when he dies, immediately
  36. 1 point
    Still weak AF...funny to think that a bout of virus and pneumonia would yield a longterm strength loss, but there you have it. I went from sets of 275 on bench to 235...375+ on squats to 315. Hopefully this all sorts itself over time. Thankfully, my perspective has shifted and I have no reason to freak out or try to maintain peak strength, so I'll just plug away. Elliptical Interval templatex15mins Bench 95x10 135x10 165x8 195x6 225x4 235x2x8S 185x15 135x15 Pec-deck 4x8 (130, 140, 150, 160) Seated Row Hoist machine 45x8 90x8 100x8 105x8 Arm Hell Overhand triceps pushdowns (67.5x20x2S) Underhand triceps pull?downs (57.5x20x2S) plate-loaded Biceps Curl (25x20x2S) plate-loaded Hammer Curl (25x10, 10x10, 10x10, 0x10) So, aside from being weak as a fucking kitten, this was a pretty damned good workout. Got some cardio+workout. Got decent density. Oh, @Something Anonymous, funny story: I saw the desk man this AM and asked him why he wasn't in the back having his usual nap, and he mumbled something about having a fever yesterday...funny how his answer has no bearing on why he was wandering around at 20 minutes to 0500, but I looked at him and said "are you fucking kidding me, Alan? Have you been watching the news, bruh?" All of the older adults who were around for this all looked at each other, mouths agape, and were like WTF!
  37. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    20/03/03 SQUAT CXWX SQUAT 135x5 185x5 225x5 275x3 belt 315x5 345x5 365x5 <-- RPE 9.5, but solid form except last one PAUSE SQUATS (3 second count) 225x8 245x8,8 GHR BWx12 +25x6,6,3 AB WHEEL BWx12,12 plankx5 Squat strength seems to have returned. No idea why my squats last week were complete dogshit, but I feel much better about them now. I do feel my form is better, but I'm not quite sure what I'm doing differently.
  38. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    20/03/01 BENCH REHAB 2 BRO BENCH 95x12 135x20 185x20 225x12,10 SMITH JM PRESS (weight on machine) 90x10 140x6,9,9 SEATED NAUTILUS ROW 3P25PSx12,12,10,10 DB HAMMER CURLS superset SINGLE ARM TRI ROPE PUSHDOWNS 40x12,10,10 35x8,8,8 Had a great workout today. I was happy to be handling 2 plates on the bench again without issue. I think my rehab work is going well. I had even better developments today as I feel the shoulder impingement/bicep tendonitis symptoms are diminishing every week. Hopefully I continue this trajectory.
  39. 1 point
    Tomahawk007

    Tomahawk HUGE update with a log

    So here was my first workout doing the ultimate cluster Back squat beltless with weak sleeves cluster sets: 375 for 5, 385 for 5, 395 for 5 Front squats with slight heel elevation cluster sets: 275 for 5, 295 for 5 Glute drive with hoop circle drop set: 210 for 10 drop 160 for 5, 220 for 10 drop 170 for 5 Lying leg curl 120 for 10 drop 90 for 7, 130 for 8 drop 90 for 7 It took me a bit longer than I would like. Got to stay on track. Warm ups were probably a bit long. Plus getting used to timing. Also it was a busier day at the gym and more of gym bros were there than usual lol. More volume than I had been doing. Felt good to do back squats for the first time in a good while. Wasn't sure how they would be beltless since I have not gone beltless on them in a LONG time. I feel like I noticed a difference on strength with the belt on the squat the most. Will be fun to see how much I can push my squat without it.
  40. 1 point
    Burton

    Liftin' weights and other shit

    I just feel like a fat sloppy turd when doing them. It's probably because my hips are weak and I have to do every fucking thing in my power to stop my knees from bowing inward. You can't really tell from that video angle, though.
  41. 1 point
    Emperor G_D

    GF's "CS Goes Pubic" Log

    I don't think it's likely that you put lots of fat on as much as you got your water balance all fucked up and were retaining water.
  42. 1 point
    Burton

    Liftin' weights and other shit

    Been plugging along working out. No reason to really bore you with my basic shit like 115 pound squats and 95 pound bench press sets. I did however wanna share with you for your eyeballs a couple of videos of my SSB squats as I'm sorta happy with my form. I'm really pushing to keep my form decent when I start and obviously lift beltless for a long while. Anyway, here's two sets of safety bar. https://drive.google.com/file/d/1BKTxahQnAsC-mthd0fNe8FJT5sUOctYn/view?usp=drivesdk https://drive.google.com/file/d/1BHqL17Q1aARcRcbQ9nN1MrssBiXSj6by/view?usp=drivesdk I'm not 100% happy with them but they're not even close to as ugly as some shit I've done in the past. I get a little relaxing of the upper back as I come up but I can fix that. I'm happy with depth and back angle overall. Anyone have any thoughts? Tonight is squat night and can always use feedback. And here's a real fucking ugly set of belt squats that I'm throwing in for luls. I need to get better at them. So ugly. Might drop the weight to nothing if I have to in order to work on the movement. https://drive.google.com/file/d/1BVKBdY22TRhDGiNeEltb9imE4kWEsDfe/view?usp=drivesdk Also, let me know if these links don't work. I'm not good at Google drive.
  43. 1 point
    Growth Factor

    GF's "CS Goes Pubic" Log

    20/02/29 DEADLIFT C1W4 DEADLIFT 315x3x3 SSB SQUAT 245x5,10,10,9 SSB PIN GOODMORNINGS 205x12,12 HANGING VUPS BWx9,7,7 Decent deload workout. I am glad I stuck with the squats and pushed for sets of 10. They felt good. While very light and unchallenging, I did like how powerful and fast my deadlifts felt. It makes me wonder whether perhaps the reintroduction of BO rows contributed to this at all. Either way, I plan on sticking with the BO BB rows. They're just too important of an exercise for me, it seems.
  44. 1 point
    Tomahawk007

    Tomahawk HUGE update with a log

    Workout for today: 249 😕 Zercher squats cluster set 305 for 5 Close grip floor press with axle bar RP 305 for 3,1,1 but it did seem easier than last week. Not as close to it coming back down on me lol Incline DB press slow negatives 85 for 11 DB lateral raise a bit of partials 45 for 11, 7 then superset for pressing for 7
  45. 1 point
    Tomahawk007

    Tomahawk HUGE update with a log

    Workout today: 249, that is a little disappointing, was hoping it would go down more after getting to that number by Tuesday(early) Pendlay rows rest pause 295 for 8,4,3 1" DB Romanian deadlifts 60 for 12 slow negatives. Was going to do the Hyper extension but it was occupied Straight arm pull down 70 for 13,3,3,3,3,3 Might need to use a different station to progress because 80 was a BIG difference Cable curl 100 for 12,3,3,3,3 So I met up with Hayley for coffee. She apparently doesn't drink coffee lol. But I wanted to do something a little low key for first time meeting. Not trying to do a big date or something that adds pressure. We just sat and talked for a good while. Good flow of conversation. Got to get a better sense of who she is. I like what I know so far and hope to get to know her more. I brought Monopoly Deal Millionaire(card game). We had talked about how we both like game nights and she liked Monopoly. Still wasn't sure how it would go. She seemed to enjoy it and we played a couple games(much quicker than the board game lol). Good chance to be a little competitive and playful. Actual date was brought up. So hopefully we can figure out when that can happen. Doesn't seem like schedule is going to line up. She has family coming into town this weekend. I will be out of town next weekend. Shouldn't be tough to see someone who lives in the same town as you lol. So here is something odd. I got on OKCupid recently. Usually I would get on POF BLEEEHHHHH lol. I have messaged a few women and actually gotten responses back lol. Like having engaging conversations. Not the internet dating I am used to at all lol. More funny than anything. Most are a good distance away anyway.
  46. 1 point
    Emperor G_D

    GF's "CS Goes Pubic" Log

    Snow. Moose. Cold. Nope.
  47. 1 point
    Science News Antianxiety and antidepressant effects from a single dose of psychedelic drug persist years later in cancer patients January 28, 2020 Following up on their landmark 2016 study, researchers at NYU Grossman School of Medicine found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients. These effects persisted nearly five years after the drug was administered. In the original study, published in the Journal of Psychopharmacology, psilocybin produced immediate, substantial, and sustained improvements in anxiety and depression and led to decreases in cancer-related demoralization and hopelessness, improved spiritual well-being, and increased quality of life. At the final 6.5-month follow-up assessment, psilocybin was associated with enduring antianxiety and antidepressant effects. Approximately 60 percent to 80 percent of participants continued with clinically significant reductions in depression or anxiety, sustained benefits in existential distress and quality of life, as well as improved attitudes toward death. The present study, publishing online Jan. 28 in the same journal, is a long-term follow-up (with assessments at about 3 years and 4.5 years following single-dose psilocybin administration) of a subset of participants from the original trial. The study reports on sustained reductions in anxiety, depression, hopelessness, demoralization, and death anxiety at both follow-up points. Approximately 60 percent to 80 percent of participants met criteria for clinically significant antidepressant or anxiolytic responses at the 4.5 year follow-up. Participants overwhelmingly (71 to 100 percent) attributed positive life changes to the psilocybin-assisted therapy experience and rated it among the most personally meaningful and spiritually significant experiences of their lives. "Adding to evidence dating back as early as the 1950s, our findings strongly suggest that psilocybin therapy is a promising means of improving the emotional, psychological, and spiritual well-being of patients with life-threatening cancer," says the 2016 parent study's lead investigator, Stephen Ross, MD, an associate professor of psychiatry in the Department of Psychiatry at NYU Langone Health. "This approach has the potential to produce a paradigm shift in the psychological and existential care of patients with cancer, especially those with terminal illness." An alternative means of treating cancer-related anxiety and depression is urgently needed, says Ross. According to statistics from several sources, close to 40 percent of the global population will be diagnosed with cancer in their lifetime, with a third of those individuals developing anxiety, depression, and other forms of distress as a result. These conditions, experts say, are associated with poorer quality of life, increased rates of suicide, and lowered survival rate. Unfortunately, conventional pharmacologic treatment methods like antidepressants work for less than half of cancer patients and tend to not work any better than placebos. In addition, they have no effect whatsoever on existential distress and death anxiety, which commonly accompany a cancer diagnosis and are linked to a hastened desire for death and increased suicidality, says Ross. The researchers say psilocybin may provide a useful tool for enhancing the effectiveness of psychotherapy and ultimately relieving these symptoms. Although the precise mechanisms are not fully understood, experts believe that the drug can make the brain more flexible and receptive to new ideas and thought patterns. In addition, previous research indicates that the drug targets a network of the brain, the default mode network, which becomes activated when we engage in self-reflection and mind wandering, and which helps to create our sense of self and sense of coherent narrative identity. In patients with anxiety and depression, this network becomes hyperactive and is associated with rumination, worry, and rigid thinking. Psilocybin appears to acutely shift activity in this network and helps people to take a more broadened perspective on their behaviors and lives. For the original study, the NYU Langone team provided 29 cancer patients with nine psychotherapy sessions, as well a single dose of either psilocybin or an active placebo, niacin, which can produce a physical flush sensation that mimics a psychedelic drug experience. After seven weeks, all participants swapped treatments and were monitored with clinical outcome measures for anxiety, depression, and existential distress, among other factors. Although researchers found that the treatment's antianxiety and antidepressant qualities persisted 6.5 months after the intervention, little was known of the drug's effectiveness in the long term. The new follow-up study is the longest-spanning exploration of psilocybin's effects on cancer-related psychiatric distress to date, the study authors say. "These results may shed light on how the positive effects of a single dose of psilocybin persist for so long," says Gabby Agin-Liebes, PhD candidate, lead investigator and lead author of the long-term follow-up study, and co-author of the 2016 parent study. "The drug seems to facilitate a deep, meaningful experience that stays with a person and can fundamentally change his or her mindset and outlook," she says. Agin-Liebes, who is pursuing her PhD in clinical psychology at Palo Alto University in California, cautions that psilocybin does not inherently lead to positive therapeutic effects when used in isolation, and in uncontrolled, recreational settings, and "should be taken in a controlled and psychologically safe setting, preferably in conjunction with counseling from trained mental health practitioners or facilitators," she adds. Next, the researchers plan to expand this research with larger trials in patients from diverse socioeconomic and ethnic groups who have advanced cancer-related psychiatric and existential distress. "This could profoundly transform the psycho-oncologic care of patients with cancer, and importantly could be used in hospice settings to help terminally ill cancer patients approach death with improved emotional and spiritual well-being," says Ross. Journal Reference: Gabrielle I Agin-Liebes, Tara Malone, Matthew M Yalch, Sarah E Mennenga, K Linnae Ponté, Jeffrey Guss, Anthony P Bossis, Jim Grigsby, Stacy Fischer, Stephen Ross. Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer. Journal of Psychopharmacology, 2020; 34 (2): 155 DOI: 10.1177/0269881119897615
  48. 1 point
    ozzman

    How to get TRT with normal test ratings?

    Working out 6 times a week with high RPE is a recipe for stagnation. With age we don't recuperate as easy. Once you get your labs and know fir aure where you stand. Try decreasing the workouts, think like a hard gainer. Or you could change going from gym workouts to street or park or anything that strikes your fancy. TRT is a forever road that you have to be serious about before undertaking.
  49. 1 point
    Sanction

    Breakfast

    https://www.telegraph.co.uk/news/health/news/7540732/A-high-fat-breakfast-of-bacon-and-eggs-may-be-the-healthiest-start-to-the-day-report-shows.html
  50. 1 point
    Kimbo

    Breakfast

    Although maybe eating a fat-based breakfast might work for that purpose.
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