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Showing content with the highest reputation on 11/21/2019 in all areas

  1. 2 points
    Construct

    The Sleep Thread 😴

    Trazodone and the mCPP metabolite have a long list of affinities. 5-HT2A and a1 antagonism are at the top of the list for Trazodone. Trazodone is also a 5-HT2B antagonist. There are some studies showing that 5-HT2B antagonism blocks the effects of SSRIs. I've been having good luck with about 1/10th of a 50mg Trazodone pill at night. If I wake up before 4AM, I nibble off another tiny piece and go back to bed. The dose is so small that I thought it might be placebo, but my sleep is objectively much worse if I don't take it. That 5-HT2A antagonism is potent.
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