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dr. frankenstein

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  1. . Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy https://www.frontiersin.org/articles/10.3389/fphys.2018.00635/full "the critical role for activated satellite cells in response to a hypertrophic stimulus is to participate in extracellular matrix remodeling which ulitmately facilitates growth, at least in Type 2 fibers" .
  2. ....some time ago when i lost sexual function from nolvadex, rescuing the stuff (almost) i have to take some oral estradiol.... not the same thing (localized is much better)(brain) ....but i worked Localization of testosterone-sensitive and sexually dimorphic aromatase-immunoreactive cells in the quail preoptic area https://www.sciencedirect.com/science/article/abs/pii/0891061896001494 Steroid control and sexual differentiation of brain aromatase https://www.sciencedirect.com/science/article/abs/pii/S0960076097800301 Rapi
  3. . Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation https://journals.physiology.org/doi/full/10.1152/physiol.00019.2017 Satellite Cell-Independent Hypertrophy During Mechanical Overload. "which provides strong evidence that myonuclear accretion cannot facilitate hypertrophy in adulthood" “satellite cells themselves do not drive adult muscle fiber growth” Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice https://link.springer.com/article
  4. . Metabolite Supplement Boosts Health and Lifespan in Mice https://www.genengnews.com/news/natural-metabolite-supplement-boosts-healthspan-and-lifespan-in-mice-clinical-trial-planned/ "Middle-aged mice that had a naturally occurring metabolite, alpha-ketoglutarate (AKG), added to their regular diets remained healthier as they aged, and experienced a dramatically shorter time of disease and disability before they died, when compared with control animals, according to the results of a double-blind study carried out by a team at the Buck Institute for Research
  5. . Short-term muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates https://journals.physiology.org/doi/abs/10.1152/ajpendo.00360.2019 "1 week of muscle disuse induces a rapid and sustained decline in daily myofibrillar protein synthesis rates in healthy young men." .
  6. . ...no bad Novo Nordisk’s semaglutide demonstrates superior weight loss versus placebo in STEP 4 trial https://www.clinicaltrialsarena.com/comment/novo-nordisk-semaglutide-weight-loss/ "The study reports that following an initial 20-week period, the 803 people who reached the target dose of semaglutide 2.4mg had a reduced mean body weight from 107.2kg to 96.1kg." "The primary endpoint of the trial was achieved by demonstrating that, of all randomised patients, those who continued with semaglutide 2.4mg for 48 weeks, following the initial 20
  7. . I mean, for hypertrophic purposes... Effects of high-intensity intermittent exercise on the contractile properties of human type I and type II skeletal muscle fibers https://journals.physiology.org/doi/full/10.1152/japplphysiol.00014.2020 ...a decrease in specific force only in type II muscle fibers... .
  8. . Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model https://journals.physiology.org/doi/full/10.1152/ajpendo.00479.2019 .
  9. . Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity https://journals.physiology.org/doi/full/10.1152/ajpendo.00539.2019 "Our results show that severe restriction of dietary carbohydrates characteristic of ketogenic diets reduces body fat accumulation, enhances energy expenditure, and reduces prevailing glycemia and insulin resistance compared with carbohydrate-rich, high-fat diets. Moreover, severe restriction of dietary carbohydrates also results in functional, morphological, and molecular changes in pancreatic islets highligh
  10. . Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor https://journals.physiology.org/doi/full/10.1152/ajpendo.00325.2019 "Bromocriptine, a dopamine D2 receptor agonist originally used for the treatment of hyperprolactinemia, is largely successful in reducing hyperglycemia and improving glucose tolerance in type 2 diabetics. However, the mechanism behind bromocriptine’s effect on glucose intolerance is unclear. Here, we tested three hypotheses, that bromocriptine may exert its effects on glucose metabolism by
  11. . Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity https://journals.physiology.org/doi/full/10.1152/ajpendo.00516.2019 ...HFD or GC treatment induced similar fat mass expansion with comparable distribution between SAT and VAT depots. However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher h
  12. . definitively hypertrophy on tipe II muscle cells (as known) 10 mg daily, 10 weeks. Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women https://journals.physiology.org/doi/full/10.1152/japplphysiol.00893.2019 ...induced significant accretion of total lean mass (+1.9%, P = 0.002) and leg lean mass (+2.4%, P = 0.001). On the muscle fiber level, testosterone increased mixed-fiber cross-sectional area (+8.2%, P = 0.001), an effect primarily driven by
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