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Construct last won the day on June 2

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  1. Those Ashwagandha results are almost too good to be true: That second part about decreasing exercise-induced muscle damage with stabilization of serum creatinine kinase caught my attention. I've been trying 300mg of KSM-66 Ashwagandha once daily. So far I've noted some welcome stress reduction. I think I need to reach the 300mg twice daily dosing scheme of the studies to really test it out. My most recent workouts haven't produced as much extreme soreness and post-workout malaise, so that's promising.
  2. I've used my new Philips Smartsleep for two nights now. I'm reserving judgment until I've used it for a few months, but I will say that my initial impression is positive. My deep sleep duration increased significantly relative to what the Zeo reported recently. Obviously I can't know for sure if the increase is due to the claimed SWS enhancing effect of the Smartsleep or just different measurement methods, but my energy levels have been notably higher in the past two days despite only getting 6 hours of sleep each night. The Smartsleep has an option to disable the SWS boosting function. After I have a few more weeks of data I'll try turning it off for a while to measure any differences.
  3. "Post-treatment Lyme disease syndrome" is the new term for symptoms like fatigue and depression that persist long after the Lyme disease has been treated. It's a welcome change away from the "chronic lyme" misnomer that implied that the infection could persist chronically. The new phrase hasn't resolved the battle, though. The idea behind "Chronic Lyme" was that the medical tests for Lyme couldn't be trusted. The chronic lyme proponents ("Lyme Literate MDs") pushed the idea that Lyme could only really be diagnosed through a list of vague symptoms, including fatigue, depression, poor concentration, and other non-specific symptoms. If someone has an unexplained illness, "chronic lyme" is a seductively simple explanation when doctors can't otherwise tell you what's wrong. If the patient is convinced that the medical tests can't be trusted anyway, it becomes very difficult to convince them that they don't have "Chronic Lyme" disease. That's not to discount the pain and suffering of these patients. I have no doubt that the difficulties of the "chronic lyme" sufferers are very real. It's the diagnosis that is the problem. As best we know, the lyme disease does not persist after treatment, even if certain symptoms do linger. Focusing on the idea of persistent infection and the associated fixation on perpetual high-dose antibiotics is counter-productive, to the point of harming patients at the extremes.
  4. I'm thinking the increased dry matter intake was related to the reduced BHB levels. I always wondered if BHB had some mild affinities for the same receptors that GHB binds too. Apparently I'm not alone in that thought: https://www.ncbi.nlm.nih.gov/pubmed/17011713 Last time I looked into this, I couldn't find any legit information supporting that theory, though. I would think that maintaining high BHB levels is the single biggest factor in the mental feeling, after the adaptation phase. Have you tried adding MCT oil to your diet? Warning: You will want to start very low with the MCT oil doses.
  5. I don't sleep walk on Ambien, fortunately. The few times I've had to be awake in the middle of the night on Ambien I've been fully aware of my medicated state and my limitations. It helps to take the lowest available dose. As for long term effects: I've never noticed much in the way of tolerance to Ambien, but I can't imagine someone could dose a GABA-related drug night after night without inducing some GABAergic changes. I can't provide any evidence for that, but I'd prefer not to risk it.
  6. I certainly don't think Ambien is great for long-term health. If I could get back to 7-8 hours of sleep most nights then I'd gladly abandon the Ambien plan. Right now, Ambien is the lesser of two evils in my book. It's a short to medium term solution while I work on cutting some other stressors out of my life. Sleep deprivation itself has some correlations with Alzheimer's disease severity: http://www.jneurosci.org/content/early/2019/06/17/JNEUROSCI.0503-19.2019
  7. For some reason my doctor has reversed her opinion on Ambien. Now believes it to be the superior choice over Trazodone for sleep quality. I didn't have time to ask why, but I did specifically ask for the CR version instead of the regular instant release version. I also asked for the lowest available dosage to play it safe. So far, I like the CR version much better than regular old Ambien. Comparing the pharmacokinetics shows the additional area under the curve for the CR over the IR. The absolute differences at the 7-8 hour mark isn't massive, but subjectively the CR is much better than the IR for staying asleep through the night. I collected Zeo data for a week before switching and I'll collect a week after switching. My sleep fragmentation, overall sleep duration, and early morning waking were worse than I was admitting to myself. Seeing the 60/100 Zeo sleep score multiple days in a row put it in perspective for me, hence the return to the doctor. Maybe the Zeo has more value than I gave it credit for.
  8. Is your mental bar too high? My gym satisfaction went way up after I lowered my expectations. Now I'm satisfied even if I show up, do my stretches, and then decide I'm not up for the task. Just getting to the gym and doing some stretches is still really satisfying.
  9. How does the elliptical treat your back? I've always wondered if those are really as low impact as they look. Are you still using a CPAP?
  10. These grumpy gym reviews are great. Can we vote on your next gym? I'm totally voting for a Crossfit gym. Can't wait to see those WOD posts.
  11. https://www.nature.com/articles/s41598-019-44097-3?utm_source=share&utm_medium=ios_app Now obviously this has a huge correlation component as those in poor health won’t be outdoors as much in the first place. However, you can’t spend 2 hours outside without getting at least a little bit of sunlight, exercise, and mental stimulation. from new scenery.
  12. In the new wave of Millennial Medicine (TM) all health problems are solved through a combination of psychedelics and CBD oil. One of the AA founders is known to have considered LSD as part of the treatment process. It's not entirely clear to me how seriously he considered it, because most of the modern-day accounts feel like they've been embellished a bit. Regardless, it did come up at one point.
  13. It depends on the woman you're dating and what she values. For most people, room mates are understood to be just room mates, regardless of gender. Non-issue. Adults are capable of handling themselves. However, you could easily find someone in your circles who was raised to believe that the only appropriate situation for a man and woman to live in the same building is as husband and wife. I've seen this among my very religious friends. For them, your living arrangements could raise some concerns. The concerns would be without merit, of course, but that doesn't matter if it's perceived as an issue.
  14. That's very interesting. Would that dose be suppressive enough that they'd have to PCT upon discontinuation? Although if they've already competed and already been tested then I suppose they might not be too concerned.
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