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  1. Colchicine is typically used in doses of 0.6mg to 1.2mg to prevent gout flare-ups. It's not entirely without side effects, but it's generally well tolerated. More recently, Colchicine has been observed to have some value in prevention of heart disease: More info in the full paper here: https://www.clinicaltherapeutics.com/article/S0149-2918(18)30596-4/pdf . The authors suggest that 0.5mg/day of Colchicine could have significant value in preventing heart disease, albeit as a second-line treatment. To date, most Colchicine trials have used 1mg/day do
  2. It's a strange effect. What dose were you taking? I've wondered if most products on the market are overdose in an attempt to make the up-front effects more noticeable. It's possible that a much smaller dose would work better for long-term maintenance.
  3. There is (or was) a decent open source community of people hacking their CPAP machines and writing software to log their function. If you're adventurous, you could try setting up a software logging solution. Does the chin strap help? I don't have a CPAP obviously, but I've tried used surgical tape to keep my mouth closed at night. Sounds crazy but my dentist recommended it. It made me less dehydrated and less congested in the mornings, but not enough that I wanted to continue dealing with it every night. Chin strap would be a much more elegant solution.
  4. In my experience, the days with bad PM2.5 pollution are visible to the naked eye as long as you can see some distant landmarks. The 100-400 PM2.5 days are visibly bad, especially with smoke particles in the air. You probably wouldn't be very excited to go outside on the really bad days anyway. Air pollution is becoming a popular research topic. There are an increasing number of studies with tentative links between air pollution exposure and various negative health effects. I went ahead and put HEPA air purifiers in my house and my office (back when that was a thing) so I could at l
  5. PurpleAir has a worldwide map of their sensor readings: https://www.purpleair.com/map?mylocation
  6. 1-2 tablespoons of MCT oil doesn't bother my stomach much when mixed with normal meals. The problem with the meal replacement shakes is that the powder doesn't have much volume. It's a very dense drink, so there isn't much to buffer the 60mL of oil in your stomach.
  7. Each meal replacement shake requires 60ml of oil or 120ml of heavy whipping cream. 60ml of MCT oil would create an intestinal disaster for even the most seasoned keto dieters. Last time around I used 15mL MCT oil / 45ml Avocado on some shakes. That's about the upper limit that my digestive system can handle.
  8. It's time for my annual month of keto. This time around I'm planning to use shakes for 50% or more of my diet. I'm using Ketochow ( https://www.ketochow.xyz/ ) this time around. Heavy cream tastes the best, but I'm also trying some avocado oil for maximum monounsaturated fat intake. I still have concerns about consuming too much saturated fat. Avocado oil is a fairly neutral tasting oil, but convincing myself to drink these avocado oil shakes is harder than I thought it would be. Hoping it gets easier as time goes on.
  9. It was anxiolytic on the surface, but it simultaneously made me feel more anxious in ways that were difficult to pinpoint. Somewhat calm, but slightly irritable like SA experienced.
  10. Same here. For me, it's a strange mix of apathy and subtly heightened background anxiety. I've wondered if a lower dose might make more sense, but I haven't tried it.
  11. That's very interesting. Thanks for thinking of me. I'll investigate this line of thinking. Really, I'll investigate any possible leads at this point. Strangely enough, I can trigger my leg soreness by doing purely upper body work now. The soreness is bearable, but it's the general malaise and mental fog that really causes problems. I've been taking a convenient break from heavy lifting until the pandemic blows over. Really starting to miss it, though.
  12. It's the hiring manager's job to decide. Don't try to make the decision for them. Apply with your best, most polished resume and see what happens. Hiring is a numbers game. Even if you don't get the job, the experience of applying and interviewing will level up your interviewing skills. The more you hone your resume, refine your pitch, and practice interviewing, the better prepared you're going to be when the right job comes along.
  13. I'm hardly an expert on Clomid, but most negative anecdotes I read online start out positive and then slide into weird side effects after a few weeks. It would be interesting to see how Enclomiphene treated the same population. I speculate it's the estrogenic isomer/metabolites of racemic clomiphene building up over time.
  14. Health still moving in the right direction? Clomid and its active metabolites have extremely long half-lives. IIRC, the more estrogenic isomer sticks around longer than the anti-estrogenic isomer and some of the metabolites can stick around for over a month.
  15. I agree. I don't think I've ever consumed more than 1/4 of a bottle at a time, but that's plenty. It's a decent blend of supplements that work and supplements that might or might not help, but can't hurt. I do wish that someone would make a similar mixture in bulk powder form, though. The brand name 5 hour energy bottles are expensive.
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