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Construct last won the day on December 25 2019

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  1. This is one of my wife's favorite videos on the topic:
  2. You sound like those insufferable people on /r/childfree Seriously though, all of my friends with young children are generally extremely happy with their children, despite the challenges. Anecdotally, most of the parenting problems or unhappiness I've seen can be traced back to the parents' relationship problems rather than the kids.
  3. Congrats on the baby. How have the first few months been?
  4. The only time I felt noticeable effects from CBD oil was when I used a full-spectrum oil, consumed a significant amount (50-100mg CBD), consumed it with a high-fat snack, and waited about 2 hours. If your'e comparing it to something more immediate and noticeable like alcohol, you're going to be disappointed. In fact, CBD is a bit disappointing all around relative to some of the marketing material out there. I think there might be some subtle effects, but it's nowhere near the miracle anxiety relief like some of the marketing material claims.
  5. Construct


    I can't find much info on Dynamine (Methylliberine). I came across this questionable toxicological assessment document: https://aibmr.com/wp-content/uploads/2018/01/CS-Poster-2019.pdf Nootropics Depot has a blog post heavy on marketing materials: https://nootropicsdepot.com/articles/dynamine-methylliberine-a-fast-acting-natural-ingredient-that-boosts-focus-and-energy/ My takeaways from the ND blog post are that it's 1) Short acting and 2) Potentially underwhelming as a stimulant if you're expecting a caffeine-like punch. Being mild and short-acting would make it a good pre-workout stimulant, though.
  6. Construct


    Looks like we had it, but the FDA pulled it. This article says it was something similar to eszopiclone: https://www.fda.gov/drugs/medication-health-fraud/public-notification-u-dream-full-night-contains-hidden-drug-ingredient Maybe some RC z-drug? Or just a regular old benzo derivative? EDIT: Other articles are saying it's racemic zopiclone, My favorite is still the workout supplement that contained Prozac for some unknown reason.
  7. Holidays are a difficult time to end a relationship, but at least you can start the new year with a clean slate.
  8. I finally got my full genome sequencing results through Promethease. The entries have a reasonable "magnitude" rating from 0 to 10, corresponding to how interesting the variant is for your health: https://www.snpedia.com/index.php/Magnitude Of the 80,000+ variations in my report, less than 10 of them came back with a magnitude higher than 2.0, and half of those were more informational than anything (gender, eye color). Only 2 or 3 of those high-magnitude variants related to health conditions that I should watch for in my old age. One of them related to the disease that ultimately killed my grandmother, so I'll be watching that closely in my 60s. Several of my high magnitude variations were for autosomal recessive disorders that cause severe problems in children who inherit bad genes from both parents. We got my wife tested as well just to be safe. Fortunately, no overlap in our autosomal recessive variants.
  9. Thanks @D-termine. I might have to buy some of those to have on hand.
  10. That's the big question in my mind. If the malaise is a broken, superficial reaction to exercise then I think it makes sense to push through it. I want to maintain as much muscle mass and fitness as possible until this hopefully passes. On the other hand, I worry that this is my body's way of telling me to knock it off because something is genuinely wrong. Latest round of blood tests came back. I don't have the raw numbers yet. The doctor says everything was normal except I have evidence of an EBV infection. This is the 3rd time in my life that I've had CFS symptoms with a positive EBV test. Going to take it easy for a month or two. Rest up and see if I improve. Might try to coordinate with a specialist to track down this EBV thing in further detail, but it's not exactly a treatable condition.
  11. That escalated quickly. No company is perfect, but IMO it doesn't take much effort to be a decent place to work. Especially at large scale tech companies where the revenue per employee leaves plenty of margin for taking care of people. I'm ambivalent about the superficial perks like company parties, expensive off-site retreats, snack rooms stocked with junk food, ping pong tables, and the other perks that companies like to advertise. Just give me open communication, clear directives, market-rate pay, good health insurance, reasonable transparency, and an environment of mutual respect.
  12. Thanks guys. This is the frustrating part. I'm barely breaking a sweat at the gym. I feel great afterward. Then 24-36 hours later, the malaise hits hard. I temporarily pulled myself out of the malaise for a meeting this week with a mix of ALCAR, Creatine, D-Ribose, NAC, CoQ10, PQQ, and L-Methylfolate. Basically one of every supplement I had on hand. It worked for about 6 hours, but now I'm the crazy supplement guy. I'm scheduling another appointment with my doctor. We didn't get very far last time, so this time I'm going in with a list of tests to ask for. Reading between the lines at work: I'm 95% certain that our US offices are gearing up for major layoffs. I'm also about 75% certain that my team is getting hit. I'm in a very fortunate position where getting laid off wouldn't be a big deal to me, but I'm getting quite stressed about my team. One guy just bought a new house. Another has a new child. Another has been crushing it by going above and beyond lately. I hate feeling helpless to change the course that the company's on.
  13. I've been going to the gym about twice a week. Haven't been great at logging it, though. Most recent trips: Friday, 29 November 2019: Bouldering: Light Pullups: Some Deadlift: 5 x 135, 225, 225, 225, 255 Sunday, 1 December 2019: Rowing machine: 5 minutes, moderate intensity Benchpress: 5 x 135, 155, 175, 185, 195, 205, 135 Felt good to lift slightly higher weights and add some cardio back. Unfortunately I'm paying for it today with a major crash. I can deal with the physical pain, but it's the brain fog that gets me.
  14. I never got vivid dreams from Trazodone. I do get the nasal congestion at the full 50mg dose, but it's mild enough to ignore at 5mg. Lot of pain in that guy's post.
  15. Trazodone and the mCPP metabolite have a long list of affinities. 5-HT2A and a1 antagonism are at the top of the list for Trazodone. Trazodone is also a 5-HT2B antagonist. There are some studies showing that 5-HT2B antagonism blocks the effects of SSRIs. I've been having good luck with about 1/10th of a 50mg Trazodone pill at night. If I wake up before 4AM, I nibble off another tiny piece and go back to bed. The dose is so small that I thought it might be placebo, but my sleep is objectively much worse if I don't take it. That 5-HT2A antagonism is potent.
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