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Construct

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  1. Surprisingly, Rapamycin pretreatment extend's ketamine's antidepressant effects: https://www.nature.com/articles/s41386-020-0644-9 However, it seems to have more to do with the fact that peripherally administered Rapamycin has limited penetration into the central nervous system. I'm glad they're also studying the (2R,6R)-hydroxynorketamine metabolite. Supposedly it doesn't have the same dissociative effects or abuse potential as ketamine, yet retains the antidepressant effects.
  2. Same here. Too many of the anti-mask arguments revolve around moving the goalposts, or otherwise showing that masks aren't 100% effective. We know they aren't 100% effective. We know that wearing a mask won't make you immune from contracting or spreading infection. We know that mask mandates alone aren't sufficient to stop the virus at this point. However, those seem to be the same few strawman arguments that the anti-mask crowd continues to use to prop up their argument. The reality is that this whole pandemic thing is a game of managing R0. If R0 > 1, infection gro
  3. Had to move my office to the frigid, uninsulated basement and I keep the thermostat turned down. I grab the kettlebell whenever I start feeling too cold.
  4. Losing access to gyms put a dent in my physical activity, but at least I could get outside. Now that the snow is falling, I'm struggling a bit. I've started doing pushups and kettlebell swings near my desk throughout the day. The downside is that I don't get any continuous exercise to break a sweat.
  5. At this point, I have more cloth masks than days of the week. Wouldn't be difficult to rotate them. I don't even leave the house more than once a week right now, so it probably doesn't matter.
  6. Colchicine is typically used in doses of 0.6mg to 1.2mg to prevent gout flare-ups. It's not entirely without side effects, but it's generally well tolerated. More recently, Colchicine has been observed to have some value in prevention of heart disease: More info in the full paper here: https://www.clinicaltherapeutics.com/article/S0149-2918(18)30596-4/pdf . The authors suggest that 0.5mg/day of Colchicine could have significant value in preventing heart disease, albeit as a second-line treatment. To date, most Colchicine trials have used 1mg/day do
  7. It's a strange effect. What dose were you taking? I've wondered if most products on the market are overdose in an attempt to make the up-front effects more noticeable. It's possible that a much smaller dose would work better for long-term maintenance.
  8. There is (or was) a decent open source community of people hacking their CPAP machines and writing software to log their function. If you're adventurous, you could try setting up a software logging solution. Does the chin strap help? I don't have a CPAP obviously, but I've tried used surgical tape to keep my mouth closed at night. Sounds crazy but my dentist recommended it. It made me less dehydrated and less congested in the mornings, but not enough that I wanted to continue dealing with it every night. Chin strap would be a much more elegant solution.
  9. In my experience, the days with bad PM2.5 pollution are visible to the naked eye as long as you can see some distant landmarks. The 100-400 PM2.5 days are visibly bad, especially with smoke particles in the air. You probably wouldn't be very excited to go outside on the really bad days anyway. Air pollution is becoming a popular research topic. There are an increasing number of studies with tentative links between air pollution exposure and various negative health effects. I went ahead and put HEPA air purifiers in my house and my office (back when that was a thing) so I could at l
  10. PurpleAir has a worldwide map of their sensor readings: https://www.purpleair.com/map?mylocation
  11. 1-2 tablespoons of MCT oil doesn't bother my stomach much when mixed with normal meals. The problem with the meal replacement shakes is that the powder doesn't have much volume. It's a very dense drink, so there isn't much to buffer the 60mL of oil in your stomach.
  12. Each meal replacement shake requires 60ml of oil or 120ml of heavy whipping cream. 60ml of MCT oil would create an intestinal disaster for even the most seasoned keto dieters. Last time around I used 15mL MCT oil / 45ml Avocado on some shakes. That's about the upper limit that my digestive system can handle.
  13. It's time for my annual month of keto. This time around I'm planning to use shakes for 50% or more of my diet. I'm using Ketochow ( https://www.ketochow.xyz/ ) this time around. Heavy cream tastes the best, but I'm also trying some avocado oil for maximum monounsaturated fat intake. I still have concerns about consuming too much saturated fat. Avocado oil is a fairly neutral tasting oil, but convincing myself to drink these avocado oil shakes is harder than I thought it would be. Hoping it gets easier as time goes on.
  14. It was anxiolytic on the surface, but it simultaneously made me feel more anxious in ways that were difficult to pinpoint. Somewhat calm, but slightly irritable like SA experienced.
  15. Same here. For me, it's a strange mix of apathy and subtly heightened background anxiety. I've wondered if a lower dose might make more sense, but I haven't tried it.
  16. That's very interesting. Thanks for thinking of me. I'll investigate this line of thinking. Really, I'll investigate any possible leads at this point. Strangely enough, I can trigger my leg soreness by doing purely upper body work now. The soreness is bearable, but it's the general malaise and mental fog that really causes problems. I've been taking a convenient break from heavy lifting until the pandemic blows over. Really starting to miss it, though.
  17. It's the hiring manager's job to decide. Don't try to make the decision for them. Apply with your best, most polished resume and see what happens. Hiring is a numbers game. Even if you don't get the job, the experience of applying and interviewing will level up your interviewing skills. The more you hone your resume, refine your pitch, and practice interviewing, the better prepared you're going to be when the right job comes along.
  18. I'm hardly an expert on Clomid, but most negative anecdotes I read online start out positive and then slide into weird side effects after a few weeks. It would be interesting to see how Enclomiphene treated the same population. I speculate it's the estrogenic isomer/metabolites of racemic clomiphene building up over time.
  19. Health still moving in the right direction? Clomid and its active metabolites have extremely long half-lives. IIRC, the more estrogenic isomer sticks around longer than the anti-estrogenic isomer and some of the metabolites can stick around for over a month.
  20. I agree. I don't think I've ever consumed more than 1/4 of a bottle at a time, but that's plenty. It's a decent blend of supplements that work and supplements that might or might not help, but can't hurt. I do wish that someone would make a similar mixture in bulk powder form, though. The brand name 5 hour energy bottles are expensive.
  21. 75mg of caffeine is a decent amount. Might not be noticeable to heavily caffeine-dependent people, but that's enough to get me buzzing. It looks like the key points are: Caffeine, a choline source, L-Tyrosine, and ALCAR. 1/3 of a 5 hour energy shot might be a decent substitute. 5-hour Energy is a decent mix of caffeine, N-Acetyl L-Tyrosine (supposedly more potent than regular L-Tyrosine), Citicoline (Decently potent choline supplement), and some various vitamins and minor additions. ALCAR is cheap enough that you could add it on top.
  22. I had a similar close call with a fast-moving river when I was younger. It's amazing how quickly water can go from okay to trying to kill you. To this day I still don't enjoy being in open bodies of water. As for the phone: Did you report it stolen to your carrier? They can get it added to the blacklist so that it can't be activated by anyone else. Doesn't get your phone back, but at least makes it less valuable for whoever stole it. I have to wonder if whoever stole it was a frequent thief, or just saw an opportunity and went for it. It's fairly common knowledge that s
  23. Seems like a reach. I think people with good baseline cognitive performance are more likely to choose higher-paying desk jobs than manual labor jobs. As for standing desks: I found myself to be more alert when I was standing vs. sitting. Being in a chair makes it easier to relax. Being on your feet means you're at least minimally active, which seems to keep the brain awake.
  24. It's difficult to find good information on the D-Lactate topic. Some people in the autism community believe that reducing D-Lactate is helpful for reducing autism severity, which has attracted a lot of snake oil vendors and questionable science. Would be great if true, but I don't think the science supports it. Even the D-Lactic Acidosis scientific papers leave more questions than answers. One of the more popular papers on treating D-Lactic Acidosis claims that it was treated with a mixture of probiotics that include D-Lactate producing probiotics. That's one reason why I think pro
  25. Bumping this thread because I've been reading up on probiotics again. On the topic of long-lasting changes: I've been reading a few studies on D-Lactic Acidosis, a condition where out of control gut bacteria produce more D-Lactate than the body can handle. A few studies suggest long-term remission by alternating between antibiotics and probiotics. As far as I can tell, the ingested probiotics are more useful for destabilizing the microbiome in a way that ultimately settles into a different cluster of dominant bacteria, which may or may not contain much of the exogenous probiotic.
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