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Sanction

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Sanction last won the day on August 1

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About Sanction

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  1. I'll bet you'd lock the door if I were out till quarter to three, you cold monster. But never mind, soon this song will not be relevant to my case.
  2. I remember reading about this some years ago, and for a while visualized the path the weight would follow as I lifted.
  3. Recent 2019 publication behind paywall Oral Ketamine for Depression? The Evidence Says Not So Fast https://www.jwatch.org/na49012/2019/05/06/oral-ketamine-depression-evidence-says-not-so-fast Positive report from 2013 Daily Oral Ketamine for the Treatment of Depression and Anxiety in Patients Receiving Hospice Care: A 28-Day Open-Label Proof-of-Concept Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717203/ Positive case study from 2010 Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717203/ " S.B. was given a dose of 27.5 mg of ketamine (0.5 mg/kg) orally at home. Subsequently, her mood was greatly improved as indicated by a 45% drop in her 17-item Hamilton Rating Scale for Depression (HRSD17) score just 60 minutes after the dose. By day 15, there was a 66% improvement. " " K.H., while at home, was given a dose of 32.5 mg of ketamine (0.5 mg/kg) orally. Subsequently, his HRSD17 dropped by 37% 60 minutes after ketamine dosing. By day 8, there was a 57% improvement. " This is not deep research, I just looked for "oral ketamine"
  4. Quick, give her my contact info plz!
  5. This is your elder self stirring inside its youthful chrysalis. A very uncomfortable time.
  6. Peer support for drug cessation/reduction. It's free and is an essential part of relapse prevention. I'm not going to contribute anything more to this discussion as long as John250 exhibits no initiative and action on that.
  7. It would be a great advance to directly measure receptor binding/activation rather than inferring it indirectly as was done in the original ketamine-naltrexone study.
  8. Ahem, you made this iocaine joke last October. I've seen a local operator of an ibogaine clinic (which is now outlawed) speak at a conference about how many people were helped to get off opiates with higher-dose ibogaine. There is some sciencey support for its use in this way, so I think it is a topic worth taking seriously. Whether it works for John's amphetamine habit is not known by any of us. One large problem for John is how to get experienced guidance and support given the current legal status in the US.
  9. Ibogaine is Schedule 1 in the US, same as heroin. In higher doses it has significant safety issues.
  10. I infer from the article title that ketamine is not an opioid https://www.hopkinsmedicine.org/news/newsroom/news-releases/ketamine-isnt-an-opioid-and-treats-depression-in-a-unique-way What was news to me: - opioid receptors are always turned on at a low level, even in the absence of opioids. This low-level activity suppresses cAMP. - quashing opioid receptors with naltrexone unleashes cAMP, which suppresses mTOR, which prevents ketamine from acting on mTOR - by itself (no naltrexone) ketamine acts on mTOR without binding to opioid receptors
  11. Oddly, the abstract hardly mentions toxicity, unless hypertrophy is considered to be a toxic effect. In the FT it does cover toxicity lightly: "Laboratory testing remains a challenge for clinicians as there are over 170 variants of anabolic steroids and no single rapid test to identify every agent"... "Multivitamins consisting mostly of vitamin B1, B6, B12, nicotinamide, and linoleic acid have been shown to protect hepatocytes from AAS induced toxicity.[21]"
  12. I did and it is weird. I can do it with 10 lbs in each hand but at the lowest point my biceps or brachialis start to ache.
  13. Just a few decades of research down the drain.
  14. I assume in that scenario I am the grasshole, while you....
  15. What does ATG stand for? (I'm on a mission to ask you guys what your TLAs mean -- there are a lot of them especially from mwarren, Stendec, Sam, Kimbo... okay, just about everyone)
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