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Epsilon Alpha

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Epsilon Alpha last won the day on November 13 2014

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  1. Unfortunately use tends to be somewhat "chronic". I wonder if they can isolate if specific phytocannabinoids are responsible. After smoking a very high concentration CBD hash (something like 80% CBD) my back never felt better but I noticed-subjectively at least- very little cognitive effects. Side note:snowmobiles can absolutely fuck your back
  2. With regards to autoimmune issues amphetamine is known to increase BBB transport, might allow a slightly higher number of autoimmune neurological conditions to occur. Then there's amphetamine type drugs insanely variable effects on the immune system itself. I'm a little too busy to go more in depth but some google scholar searches for "amphetamine BBB" and "amphetamine immune system" will turn up interesting papers on the topic
  3. Interesting, if I recall fungi are also very dependent on cholesterol levels. Perhaps it fits into the Apo e4 link as well? A higher amount of cholesterol could provide a more favorable environment for fungi to grow, and as such it would be associated with an increased risk. Or conversely, fungi are just one of several organisms to cause a immune response that helps speed up neurodegredation. AD is associated with BBB dysfunction so it would put individuals at a higher risk for chronic low grade CNS infections. Still finding fungi in all the AD brains they examined does seem promising
  4. This fits nicely with the paper I wrote in 2013 regarding amphetamine induced protein aggregates. Good find, wish I had the time to work on this stuff again
  5. NAC has been shown to upregulate nitric oxide Interesting, I've never seen anything directly supporting biphasic effects of NO in this scenario. Its good to have proof now I haven't done a review of the nitric oxide/NMDA/epigenetics aspects of amphetamine use in a while. If it weren't for the ton of research I need to do for medical school I'd be all over it Seen any good papers on it recently?
  6. This might have something to do with nitric oxide levels, IIRC NAC has been shown to effect its physiological levels. NO has also been shown to be implicated in addictions will hopefully have some time to hunt for refs tonight
  7. So I thought I would rehash an older topic from the M&M days and broaden the scope of the discussion note this thread is a work in progress and I would love some help Steroid hormone Production: Sex Steroids http://www.mindandmuscle.net/forum/30890-amphetamine-s-effects-testosterone The results posted by krazyj suggest that amphetamine use prevents synthesis of several classes of steroids, notably androgens and estrogens while maintaining most if not all of the synthetic capacity to produce progestins, glucocorticoids, and mineralcorticoids. Additionally, more current findings have shown that (meth)amphetamine can cause ischemia of the testicles in man. Though this case is the only one I can find thus far it corroborates the animal data that higher dose amphetamines can cause vasoconstriction and hypoxia in the testis. Though human data is scant we also have reason to believe that amphetamine class drugs can reduce GnRH levels and tentatively reduce LH levels. Additionally, it should be considered relevant that amphetamine may damage testicular function via these mechanisms. Additionally it does not appear that amphetamine has significant effects on human prolactin levels, potentially eliminating that mechanism of amphetamine increasing androgen production and thus maintaining a potentially normal androgen level range. However this is a mixed blessing as in high dose methamphetamine studies prolactin has been found to help maintain BBB integrity Now the jury is still out on the results of this in humans at theraputic doses as no smoking gun type literature has been produced since the last thread to the best of my knowledge. Glucocorticoids Amphetamine appears to have mixed effects on cortisol levels in man, acutely increasing it and with less clear data regarding its chronic use. Interestingly high baseline cortisol is associated with increased positive subjective effects of amphetamine. Gonna stop here and get back to studying for my final.
  8. Not sure if I'm preaching to the choir here, but Alzheimer's has been linked to several metabolic issues in the brain including glucose, amino acid, and lipid metabolism. It seems reasonable that normalizing some abnormal metabolic pathways could have beneficial effects on function in these populations. I'm beginning to think Alzheimer's might be like Huntington's where it appears to have some kind of benefit earlier in life and as a consequence sacrifices health later in life. Perhaps back in the Paleocene some ancestor of ours got some kind of benefit by having genes associated with the disease http://www.isita-org.com/jass/Contents/2013vol91/Bufill/23579031.pdf apo E4 which is one of the most commonly implicated genetic link does have some protective effects against stress and hepatitis C, perhaps that was enough to select for it before E2/3 became selected for due to their probable cognitive benefits.
  9. I'd hazard a guess that it involves breaking a sympathetic feedback loop, its a major sympathetic structure. No idea how it would do that though One must wonder if all nerve blocking agents produce the same effects
  10. But what about my rampant hedonism? I do get what they mean though, when denied most pleasures there is a deep satisfaction on paring down to the efficient bare minimum and the clarity it brings.
  11. One particular pathway that has caught my interest of late is methamphetamine's ability to damage the gonads, and the subsequent effects on fertility and hormone levels. I don't have the citations on this computer, but it seems surprisingly linked to neurotoxicity. Do you think endocrine effects of amphetamines is appropriate for this thread or should I start another to discuss that?
  12. I more posted this to bring that info to this thread as you've got the collection of great threads in the OP
  13. My understanding was that trkB activation has antiapoptotic effects. There's a body of research that suggests that after the initial surge following dosing, apoptosis continues for at least two weeks following massive methamphetamine dosages so this in theory should help reduce the subsequent cell death. Anyone see what that Seppi guy posted on bluelight, he's got some interesting links in this thread that suggest that methamphetamine and amphetamine may actually have markedly different neurotoxic thresholds in humans. His main point relates to sigma receptor affinity in several recent studies. This is an issue as it may make methamphetamine to amphetamine comparisons from previous studies much less accurate than previously believed. http://www.bluelight.org/vb/threads/714707-How-is-amphetamine-neurotoxic-What-does-it-do-to-you http://www.bluelight.org/vb/threads/714707-How-is-amphetamine-neurotoxic-What-does-it-do-to-you
  14. I'm curious if this has to do with neurosteroid levels, as the peripheral benzodiazapine receptor AKA translocator protein is involved in neurosteroid synthesis. If so it could maybe tie together some of the observed mitochondrial deficits in Alzheimer's as well as the lower amounts of neurosteroids seen in the disease. Any ideas on how the use of benzo's might effect neurosteroid synthesis long term? I haven't done much digging on this topic http://www.ncbi.nlm.nih.gov/pubmed/18690831 http://www.ncbi.nlm.nih.gov/pubmed/16338086
  15. From my own experience skimming non-western drug development its actually a horrific mash up of well conducted research and bribes as far as the eye can see. The horror... The horror...
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