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Emperor G_D

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Emperor G_D last won the day on December 15

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  1. Emperor G_D

    SR9011?

    I was pretty sure I had posted a helpful pdf some time back with a whole collection of exercise mimetics and like substances. ~~~ REV-ERBa Ligands Other in vivo-tested exercise mimetics include SR9009 and SR9011, synthetic ligands of REV-ERBa, a nuclear receptor that plays a critical role in regulating circadian rhythm and energy metabolism. When activated by these compounds, REV-ERBa recruits co-repressors such as SMRT and NCOR1 and suppresses the expression of its target genes. Most metabolic genes in muscle are circadian, and thus the relative amplitudes of these circuits are REV-ERB dependent (Zhao et al., 2016). In muscle, REV-ERBa is selectively expressed in oxidative myofibers and is further induced by exercise. Its overexpression in muscle increases mitochondrial biogenesis and fatty acid metabolism, while its ablation results in the reverse effects. REV-ERBa does not directly regulate mitochondrial genes but rather may induce their expression indirectly through the AMPK-SIRT1-PGC1a pathway (Canto┬┤ et al., 2010), though the mechanism remains unclear. This action makes REV-ERBa an ideal candidate for the development of exercise mimetics. Indeed, in vivo SR9009 or SR9011 treatment mimics exercise by inducing mitochondrial biogenesis as well as fatty acid oxidation, and improves endurance performance (Woldt et al., 2013). ~~~ TBH, I assume most things on the market are tainted, or bullshit, or dangerous, and maybe it's just me being in my 40s, but I don't do much experimentation with RCs anymore. Please run it and report back...I'd be happy to run it if it were safe and effective. More often than not I wonder how much something would cost me to import and have assayed, and then when I realize that it would cost like 4 billion dollars, I wander off and find something else that is shiny to look at.
  2. Mine will be arriving today, too. I went with the linked formula above. It's straight 3,5-T2 with no 3,3. 100mcg per dose. We'll see if fasting+T2 helps my fat loss along any.
  3. Looks like Victoza might be covered for me. Good timing.
  4. 90 seconds of searching turns it up as an adjuvant to short-bowel syndrome that reverses weight loss from the SBS. I'm guessing 'no'.
  5. I bet you'd have to find a really edgy doc that you rx this for weight loss, though. I have an upcoming physical, so I might try to walk my guy down this path.
  6. So you boned your way into a mental hernia?
  7. Bench 45x20 95x10 135x10 185x5 225x3 255x1 285x2x4S 285xAMRAP (x10) 235x10 195x10 145x15 Pec-deck flyes 120x10 130x10 140x10 Reverse pec-deck 110x15 120x10 130x10 140x5, 120x5 Triceps Hell Over 57.5x20 62.5x20 Under 47.5x20 52.5x20 Superset Low cable biceps curl and standing crunch 52.5x10 72.5x15 54x10 77.5x15 59x10 82.5x15 XXX 87.5x15 Seated concentration curl done strict and slow 25x10 30x10 35x10 25x10
  8. Yes, I know that feeling all too well. Rest up, Oz.
  9. Squatengruben 45x10 135x10 185x5 225x5 275x3 315x1 380x2x4S 380xAMRAP (x10) 335x10 245x10 155x10 Sled 100x1 155x1 210x1 265x1 290x1 210x1 155x1 100x1 Need to get some ab work in...
  10. https://www.amazon.com/Nutrition-Thyro-T2-Stimulant-Metabolism-Capsules/dp/B01J9713DM?SubscriptionId=AKIAILSHYYTFIVPWUY6Q&tag=duckduckgo-brave-20&linkCode=xm2&camp=2025&creative=165953&creativeASIN=B01J9713DM
  11. I loved the original Alpha-T2, just like you Rolo.
  12. Same here. I work from home and give no shits about those perks.
  13. Jamal has an insanely smooth pull. I love to watch it. This 950 puts Eddie hall's 1100 in some interesting perspective...
  14. Bench II Incline Press 45x20 95x10 135x10 165x10 185x5 225x3 260x3x4S 260xAMRAP (x10) 230x10 190x10 140x10 Overhead cable triceps extensions 42.5x15 47.5x10 52.5x10 57.5x7 Cable Flyes 52.5x10 47.5x8 42.5x8 37.5x7 Seated Biceps Curl 25x10 35x10 40x10 45x10 40x10 35x10 25x5 Elliptical 10 minutes
  15. One of the reasons that I think Red Hat isn't awful as a place to work is that when we have our inevitable yearly re-org, it's all done out in the open. There's some stuff that goes on under the cone of silence, no doubt, but a good majority of it happens in front of us and with us taking part in the project over the course of the re-org.
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