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Growth Factor

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  1. Nat Med. 2011 Oct 2;17(10):1228-30. doi: 10.1038/nm.2435. Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Benedetti F1, Amanzio M, Rosato R, Blanchard C. Author information 1 Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience (INN), Turin, Italy. fabrizio.benedetti@unito.it Abstract Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved. PMID: 21963514 DOI: 10.1038/nm.2435
  2. What is this EDT hullabaloo over here?
  3. 19/08/07 BENCH C1W1 PAUSE BRO PRESS 135x5 185x5 225x5 275x3 295x1 315x3 <-- RPE 9.5 305x4,3 <-- RPE 10 last set CG BRO PRESS 275x4 265x6,5 CG SPOTO BRO PRESS 245x5 SEATED NAUTILUS ROW superset BAND PULLAPARTSx20 3P25PSx10,8,8,6,7 EZ PREACHER CURLS superset INCLINE EZ SKULLCRUSHERS 85x3x12 85x3x12 Thought I should be able to lift more than I did, but it doesn't look like it was in the cards today. At least I did better than the week before, and I added in more volume overall.
  4. I promise I haven't been totally worthless in the gym. Here are two recent workouts 19/08/03 OHP C1W0 OHP 95x5 115x5 135x5 175x4,5,5 PULLUPS BW@247 (prone grip) BWx5,5,5,6,5 DIPS +45x3x10 <-- too light DB HAMMER CURLS superset ROLLING DB EXTENSIONS 35x15,15,12 35x15,12,12
  5. There is speculation that they did this to market the idea that because it is weaker it is somehow less prone to abuse. That of course flies in the face of the history of mankind who would simply elect to just use more if they so wish to abuse it, similar to prescription opioids, XR tablets, dextromethorphan, bath salts, etc.
  6. Wait, this doesn't make sense. If ketamine is a NMDA antagonist (might have yet-tbd structural homology thats more alike another ligand, but until then...), then it should inhibit mTOR. Why would an MOR antagonist's downstream mTOR inhibition interfere with this? If anything wouldnt it synergize? This intrigues me. Ill have to check out the paper.
  7. I've met some interesting folks with Grindr! I wholeheartedly approve!!
  8. Blame the abstract, though tbf the paper really should have been titled "Anabolic Steroid Toxicology". The paper definitely dives into toxicological musings of AAS and explores molecular, histological, behavioral, and physiological changes in response to AAS well beyond the things some of us have taken/do take AAS for. Here's a brief example. History and Physical Cardiovascular signs of anabolic steroid toxicity[19]: Hypertension secondary to elevated systemic vascular resistance Hypercoagulative state which may result in intracardiac thromboses, venous thromboses Direct myocardial toxicity and pro-inflammatory biomarker profile, which may result in non-ischemic cardiomyopathy, myocardial infarction, heart failure Dyslipidemia Erythrocythemia Accelerated coronary atherosclerosis Hepatic system signs of anabolic steroid toxicity[20]: Cholestasis NASH Direct liver toxicity Hepatic neoplasms Decreased SHBG Hepatomegaly Bile acid nephropathy Endocrine system signs of anabolic steroid toxicity: Acne Gynecomastia (males) Virilization (females) Irregular menses (females) Hypogonadism Decreased levels of HDL Premature epiphyseal closure Neuropsychiatric symptoms of anabolic steroid toxicity: Major depression Body dysmorphic syndrome Narcissistic personality disorder Aggression Dependence Anxiety Bipolar depressive disorder Suicidal tendencies Decreased pattern recognition Just about the only thing on this list that we would not consider a toxic side effect of taking AAS would be increased aggression, especially if you personally opted for a more androgenic steroid for strength gains vs. size gains.
  9. I don't understand this setup. Could you elaborate or explain it differently?
  10. 19/07/28 BENCH C1W0 (cont) SEATED EZ PREACHER CURL (35lb bar, weight listed as weight on the bar) 20x10 40x4x10 INCLINE EZ SKULLCRUSHERS 20x10 40x4x12 FACEPULLS 2(weight, unlisted)x4x15 AB STUFF 8 sets Showering, eating, and headed to an Innumerable Forms show tonight with some gym buds.
  11. Yeah, v true wrt how you don't lose too much strength or at least are able to restore it rather fast if you do a good job at maintaining weight. I'm curious to see how the legs up bench works for you. I'm really feeling it in my pecs, which is obvious. What's not obvious (to me) is why I don't lift more with leg drive.
  12. Hey guys. I had to put a pin on that issue for the time being while I dealt with the far more pressing issue of my move, as well as dealing with an avalanche of shit at work. The avalanche is being managed, and I finally moved in to my new place! I'm all settled in here and feel like I can resume the rest of my life. I haven't even been to the gym for about 3 weeks. Today was my first today. I told a buddy of mine who helped me move yesterday that I was going to lift with him today, but I just did not want to wait until 5pm to start + I am going to a concert this evening. What I intend to do instead is finish up the rest of my workout this evening then book it on out of there ASAP. Below is what I did this morning. 19/07/28 BENCH C1W0 PAUSE BRO PRESS 135x8 185x5 225x5 275x2 295x1 315x2 <-- RPE 9+ CG BRO PRESS 275x5,4,3 BRO PRESS (TnG) 225x10 <-- RPE 9.5 SEATED NAUTILUS ROW superset BAND PULLAPARTS x20 3PPSx12,12,10 I was fairly pleased with how much I've been able to retain due to bad diet and skipping meals, in addition to not lifting. My pressing strength is really not bad. That works out to be ~92% strength retention with the time off and inconsistent eating. I've even lost about 10lbs. My strength endurance is in the toilet, but that'll catch up fast. Plus I'm sure much of that is also due to creatine loss. My back strength probably suffered the most, but I can get that back up. Also, I went thru these exercises in very quick succession, especially the back work, so my strength endurance may actually be not bad. The time between sets alone could account for much of my loss of strength endurance.
  13. Fuck that weak shit CBD. THC will really knock out your sperm's functionality. Male contraceptive stack = frequent THC + AAS </s> It's just too bad it doesn't protect you against STIs.
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