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STENDEC

RAD140

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This an interesting and apparently very potent SARM.

 

There are no human trials yet but in rats and monkeys, it showed a very favorable anabolic:androgenic ratio and in monkeys, resulted in a 10% increase in LBM over a period of just 4 weeks at a dose of 0.1mg/kg BW.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/

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They don't check for hormone levels???

 

Footnote 27 states:

(27) Since these were young, intact male cynomolgous monkeys (3 to 4 years of age), they had fairly high endogeneous total plasma testosterone at day-1 (approximately 600-800 ng/dL), which is similar to the approximately 600 ng/mL that human males have between the ages of 25 and 54 (the levels then gradually decline with age). After 28 days of dosing with RAD140, the testosterone levels in all three groups was suppressed to approximately 200-300 ng/dL, with similar suppression in all three groups, although testosterone levels were significantly different for only the 0.01 mg/kg group (p < 0.05). Although this measurement did not account for possible diurnal variations in the animals and LH levels were not definitive, since they were below the level of detection in most pre- and post-dose groups (LH<0.8 ng/mL), one might still consider the possibility that even the 0.01 mg/kg dose was a fully effective, testosterone replacement dose, since body weight and lean mass were at least maintained (if not increased) in the low dose group despite significant testosterone suppression. Beyond this finding, we do not know whether testosterone suppression is a proxy for other CNS-related androgen effects beyond LH interference, such as mood, libido, and cognition, but we do believe a SARM with potent androgen agonist, CNS-type activity would be an interesting tool for that sort of exploration,

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Footnote 27 states:

(27) Since these were young, intact male cynomolgous monkeys (3 to 4 years of age), they had fairly high endogeneous total plasma testosterone at day-1 (approximately 600-800 ng/dL), which is similar to the approximately 600 ng/mL that human males have between the ages of 25 and 54 (the levels then gradually decline with age). After 28 days of dosing with RAD140, the testosterone levels in all three groups was suppressed to approximately 200-300 ng/dL, with similar suppression in all three groups, although testosterone levels were significantly different for only the 0.01 mg/kg group (p < 0.05). Although this measurement did not account for possible diurnal variations in the animals and LH levels were not definitive, since they were below the level of detection in most pre- and post-dose groups (LH<0.8 ng/mL), one might still consider the possibility that even the 0.01 mg/kg dose was a fully effective, testosterone replacement dose, since body weight and lean mass were at least maintained (if not increased) in the low dose group despite significant testosterone suppression. Beyond this finding, we do not know whether testosterone suppression is a proxy for other CNS-related androgen effects beyond LH interference, such as mood, libido, and cognition, but we do believe a SARM with potent androgen agonist, CNS-type activity would be an interesting tool for that sort of exploration,

 

 

thanks !

 

and about the 10 % increase in LBM, please dear lecturer

 

 

 

.

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Thinking about getting some of this in powder form. Have been researching sources quite a bit and am probably going to go with IRC.bio

 

Don't know when I will get to run it lol..But it seems pretty legit for a cut or recomp and also has neuroprotective properties.

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On 02/24/2018 at 10:00 PM, Emperor G_D said:

Irc.bio?

 

I'll check it out. 

Yes sir. They are highly reviewed on Reddit.

 

Also, I'm too much of a tightwad so I got S23 instead. =D

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On 03/31/2016 at 8:59 AM, dr. frankenstein said:

.

 

 

 

ml-2010-002508_0006.jpg

 

 

ml-2010-002508_0005.jpg

I just now noticed that subjects gained more on .1mg/kg than 1mg/kg.

 

For a 200lb male that 9 mg's vs 90mg's.

And dosing is generally 20-30mg's. I'm sure appetite was crushed like when strong oral AAS are dosed too high.

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