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Methylene blue shows promise for improving short-term memory: Study in humans
 
Science Daily
June 28, 2016
 
A single oral dose of methylene blue results in an increased MRI-based response in brain areas that control short-term memory and attention, according to a new study published online in the journal Radiology.

 

Methylene blue is used to treat methemoglobinemia, a blood disorder in which oxygen is unable to release effectively to body tissues, and as a surgical stain.

 

Animal studies have shown a single low dose of methylene blue enhances long-term contextual memory--the conscious recall of the source and circumstances of a specific memory--and extinction memory, a process in which a conditioned response from stimuli gradually diminishes over time.

 

"Although the memory-enhancing effects of methylene blue were shown in rodents in the 1970s, the underlying neuronal changes in the brain responsible for memory improvement and the effects of methylene blue on short-term memory and sustained-attention tasks have not been investigated," said study author Timothy Q. Duong, Ph.D., from the University of Texas Health Science Center at San Antonio, Texas. "Our team decided to conduct the first multi-modal MRI study of methylene blue in humans."

 

Twenty-six healthy participants, between the ages of 22 and 62, were enrolled in a double-blinded, randomized, placebo-controlled clinical trial to measure the effects of methylene blue on the human brain during working-memory and sustained-attention tasks. This study was approved by the local ethical committee.

 

The participants underwent functional MRI (fMRI) before and one hour after low-dose methylene blue or placebo administration to evaluate the potential effects of methylene blue on cerebrovascular reactivity during tasks. Mean cerebral blood flow was measured pre- and post-intervention.

 

The results showed methylene blue increased response in the bilateral insular cortex--an area deep within the brain associated with emotional responses--during a task that measured reaction time to a visual stimulus. The fMRI results also showed an increased response during short-term memory tasks involving the brain's prefrontal cortex, which controls processing of memories, the parietal lobe, primarily associated with the processing of sensory information, and the occipital cortex, the visual processing center of the brain. In addition, methylene blue was associated with a 7 percent increase in correct responses during memory retrieval.

 

The findings suggest that methylene blue can regulate certain brain networks related to sustained attention and short-term memory after a single oral low dose.

 

"This work certainly provides a foundation for future trials of methylene blue in healthy aging, cognitive impairment, dementia and other conditions that might benefit from drug-induced memory enhancement," Dr. Duong said.

 

 

 
Journal Reference:
Pavel Rodriguez, Wei Zhou, Douglas W. Barrett, Wilson Altmeyer, Juan E. Gutierrez, Jinqi Li, Jack L. Lancaster, Francisco Gonzalez-Lima, Timothy Q. Duong.
Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain.
Radiology, 2016; 152893 DOI: 10.1148/radiol.2016152893

 

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For sure. They are using about 30x the dose I take which gives my pee a light azure hue.

 

Thanks for the FT rs81!!!!

 

For what reason are you taking this small dose of meth blue?

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For what reason are you taking this small dose of meth blue?

For mitochondria and neuroprotection.

 

Dosages are controversial. The dose I take is 160x greater than what's recommended some people.

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For mitochondria and neuroprotection.

 

Dosages are controversial. The dose I take is 160x greater than what's recommended some people.

 

The recommended dose must be nearly homeopathic.

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Reviving this thread, been hearing Ben Greenfield among others discussing MB as a cognitive enhancer and nootropic pick me up lately.  Considering picking some up from Ben's source here; Methylene Blue 10mg x 30ml it runs $15 for that amount.

 

As for the science, I'm not smart enough or inclined enough to read through this paper, but here's the full text;
 

Quote

 

Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue

 

Abstract

This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene blue in vivo. These mechanisms have important implications as a new neurobiological approach to improve normal memory and to treat memory impairment and neurodegeneration associated with mitochondrial dysfunction. Methylene blue’s action is unique because its neurobiological effects are not determined by regular drug-receptor interactions or drug-response paradigms. Methylene blue shows a hormetic dose-response, with opposite effects at low and high doses. At low doses, methylene blue is an electron cycler in the mitochondrial electron transport chain, with unparalleled antioxidant and cell respiration-enhancing properties that affect the function of the nervous system in a versatile manner. A major role of the respiratory enzyme cytochrome oxidase on the memory-enhancing effects of methylene blue is supported by available data. The memory-enhancing effects have been associated with improvement of memory consolidation in a network-specific and use-dependent fashion. In addition, low doses of methylene blue have also been used for neuroprotection against mitochondrial dysfunction in humans and experimental models of disease. The unique auto-oxidizing property of methylene blue and its pleiotropic effects on a number of tissue oxidases explain its potent neuroprotective effects at low doses. The evidence reviewed supports a mechanistic role of low-dose methylene blue as a promising and safe intervention for improving memory and for the treatment of acute and chronic conditions characterized by increased oxidative stress, neurodegeneration and memory impairment.


 

 

 

Reading through the comments it seems like Ben suggests starting at .5mg/kg bodyweight and going up from there.  More on MB and other fun biohacks in the show notes from Ben's podcast with Kyle Kingsbury here;

 

Smart Drugs, Nootropics, Microdosing With Psychedelics, Enhancing Deep Sleep, Rites Of Passage & Much More With Kyle Kingsbury Of Onnit.

 

@Sanction care to weigh in on your experience/dosing with MB?

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I ran out a long time ago. The supplier went out of business, and until now I haven't seen another one.

MB definitely did something. I was not rigorous or scientific in my trial so my impressions are vague.

There must be something in the collective unconcious, because I was searching for MB again 2 weeks ago after not thinking about it for 2 years,

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