Jump to content
Sign in to follow this  
STENDEC

Anavar Produces Lasting Fat Loss in Men

Recommended Posts

J Appl Physiol (1985). 2004 Mar;96(3):1055-62. Epub 2003 Oct 24.
Treatment with oxandrolone and the durability of effects in older men.
Schroeder ET1, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler FR.

Abstract
We investigated the effects of the anabolic androgen, oxandrolone, on lean body mass (LBM), muscle size, fat, and maximum voluntary muscle strength, and we determined the durability of effects after treatment was stopped. Thirty-two healthy 60- to 87-yr-old men were randomized to receive 20 mg oxandrolone/day (n = 20) or placebo (n = 12) for 12 wk. Body composition [dual-energy X-ray absorptiometry (DEXA), magnetic resonance imaging, and (2)H(2)O dilution] and muscle strength [1 repetition maximum (1 RM)] were evaluated at baseline and after 12 wk of treatment; body composition (DEXA) and 1-RM strength were then assessed 12 wk after treatment was discontinued (week 24). At week 12, oxandrolone increased LBM by 3.0 +/- 1.5 kg (P < 0.001), total body water by 2.9 +/- 3.7 kg (P = 0.002), and proximal thigh muscle area by 12.4 +/- 8.4 cm(2) (P < 0.001); these increases were greater (P < 0.003) than in the placebo group. Oxandrolone increased 1-RM strength for leg press by 6.7 +/- 6.4% (P < 0.001), leg flexion by 7.0 +/- 7.8% (P < 0.001), chest press by 9.3 +/- 6.7% (P < 0.001), and latissimus pull-down exercises by 5.1 +/- 9.1% (P = 0.02); these increases were greater than placebo. Oxandrolone reduced total (-1.9 +/- 1.0 kg) and trunk fat (-1.3 +/- 0.6 kg; P < 0.001), and these decreases were greater (P < 0.001) than placebo. Twelve weeks after oxandrolone was discontinued (week 24), the increments in LBM and muscle strength were no longer different from baseline (P > 0.15). However, the decreases in total and trunk fat were sustained (-1.5 +/- 1.8, P = 0.001 and -1.0 +/- 1.1 kg, P < 0.001, respectively). Thus oxandrolone induced short-term improvements in LBM, muscle area, and strength, while reducing whole body and trunk adiposity. Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained.

 

PMID: 14578370 


FFT

Share this post


Link to post
Share on other sites
Quote

 


The discordant effects of oxandrolone on lean tissue and fat mass 12 wk after study therapy was discontinued were puzzling. According to 3-day food diaries and self-report of exercise activity, subjects did not change their dietary or habitual activity during the study. Thus the durability of the effects of oxandrolone on adipose but not lean tissue likely reflect the biological differences in these tissues and/or the effects of other concurrent regulators of metabolism. In a population prone to obesity, it is remarkable that 80% of the reduction in total and central fat mass after a relatively short period of androgen therapy (12 wk) were sustained for at least 3 mo after treatment was discontinued. 

 

Share this post


Link to post
Share on other sites

This seems to come up oftentimes. What's the solution to this?

 

Test kits test for presence, but can't tell you potency. 

 

I guess there used to be a few GC/MS services, but I think they're gone, now.

 

Does anybody know a way or a company offering the service?

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  

×
×
  • Create New...