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John250

Proper CBD dosage?

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Nootropics Depot is getting into the CBD game now. They have some unusually hyperbolic marketing material for their first CBD product: http://nootropicsdepot.com/nextcbd-cbd-oil-softgels/

 

From what I understand, Nootropics Depot is a spin-off business from the old Ceretropic company. Ceretropic's supposedly unique edge was their high quality control, though I don't think I ever saw any real QC evidence outside of their founder's claims in Reddit posts.

 

Their marketing material claims 20x better bioavailability than regular CBD. Regular CBD has an oral bioavailability of 6-16% according to studies I've seen, so by my math this NextCBD has bioavailability of up to... 320%. Kind of disappointing to see Nootropics Depot go the way of other supplement marketing companies, but I suppose there's big money in CBD marketing right now.

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Just saw a news story last night saying that CVS is planning to sell CBD products. All topical (for now).

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6 hours ago, Construct said:

Nootropics Depot is getting into the CBD game now. They have some unusually hyperbolic marketing material for their first CBD product: http://nootropicsdepot.com/nextcbd-cbd-oil-softgels/

 

From what I understand, Nootropics Depot is a spin-off business from the old Ceretropic company. Ceretropic's supposedly unique edge was their high quality control, though I don't think I ever saw any real QC evidence outside of their founder's claims in Reddit posts.

 

Their marketing material claims 20x better bioavailability than regular CBD. Regular CBD has an oral bioavailability of 6-16% according to studies I've seen, so by my math this NextCBD has bioavailability of up to... 320%. Kind of disappointing to see Nootropics Depot go the way of other supplement marketing companies, but I suppose there's big money in CBD marketing right now.

The text of their marketing materials now make me want to revisit a lot of the CBD studies I had read in the past. I was pretty sure epileptics were smoking 200-300mg, not eating it, which would make the comparison of their product to 200mg products not make much sense. 

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I'm tempted to get some isolate powder and make my own homebrew  with MCT oil so I can get a reasonable dose per ml although I am not exactly sure what I expect from it.

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On 3/23/2019 at 8:43 AM, STENDEC said:

I'm tempted to get some isolate powder and make my own homebrew  with MCT oil so I can get a reasonable dose per ml although I am not exactly sure what I expect from it.

If you wanted to do that I'd make sure to use something that could allow for sublingual penetration to avoid gut metabolism. I have no idea how solvents affect these things, but they might. 

 

On the topic of gut metabolism, I just came across this fine article (I believe citations included):

https://www.rxleaf.com/the-ph-level-in-stomach-acid-can-convert-cbd-to-thc

 

I think this all would need to be repeated at the least before we could establish the gut angle as believable, but the part about the acidic conversion of THC to CBD is quite interesting. 

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The effects of cannabidiol on male reproductive system: A literature review

https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.3831?fbclid=IwAR2NU4tipoz2uuJsfVnFVJR5nNa2mDxOIA5cn3gDO5gYlDmAl1KIb-IqfVU&

 

https://sci-hub.tw/https://doi.org/10.1002/jat.3831

 

In short: It's bad, scary stuff...if you're a mouse, a rat, a monkey or a *sea* urchin*.

 

*- regular urchins of the corpus-scientian kind should be fine. Or at least, there's no research to prove that we won't be...

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1 hour ago, Growth Factor said:

Fuck that weak shit CBD. THC will really knock out your sperm's functionality. 

 

Male contraceptive stack = frequent THC + AAS </s>

 

It's just too bad it doesn't protect you against STIs.

 

Well, maybe when your AAS makes you into a raging meathead, and your testosterone sags and your grapes shrink, you won't catch STI because no chick will want you? lol </s>

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13 hours ago, Emperor G_D said:

 

Well, maybe when your AAS makes you into a raging meathead, and your testosterone sags and your grapes shrink, you won't catch STI because no chick will want you? lol </s>

Problem solved!

 

wait...

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"... rats that were given THC had higher levels of activated ERK, showed more anxiety behaviours ...

...another interesting finding was that CBD alone had no effect on the ERK pathway. "However, by co-administering CBD and THC, we completely reversed the direction of the change on a molecular level. CBD was also able to reverse the anxiety-like behaviour and addictive-like behaviour caused by the THC."

 

https://www.eurekalert.org/pub_releases/2019-09/uowo-csr093019.php

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I definitely enjoy the effects of a few hits of CBD. 

 

THC is another thing...it makes me paranoid. It increases the physical effects of anxiety, which is paranoia-inducing, too. That said, a hit of THC vape can also give me a relaxation so deep as I am unable to get elsewhere. After that initial heart-hammering semi-stressful reaction to it, I can eventually get relaxed like a piece of furniture.

 

That's why I say that if you live in a place where you can find cannabis-derived products, and you can get blends of CBD:THC, you can experiment with 8:1, 4:1 or 1:1 oils to find the right ratio for you.

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On 9/30/2019 at 8:37 PM, Sanction said:

"... rats that were given THC had higher levels of activated ERK, showed more anxiety behaviours ...

...another interesting finding was that CBD alone had no effect on the ERK pathway. "However, by co-administering CBD and THC, we completely reversed the direction of the change on a molecular level. CBD was also able to reverse the anxiety-like behaviour and addictive-like behaviour caused by the THC."

 

https://www.eurekalert.org/pub_releases/2019-09/uowo-csr093019.php

Ok, that's really interesting. 

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